Pediatric Intensive Care Unit, Emma Children's Hospital AMC, Amsterdam, The Netherlands.
Pediatr Crit Care Med. 2013 Jun;14(5):e243-9. doi: 10.1097/PCC.0b013e31828a7f9b.
To determine biventricular cardiac function in pneumovirus-induced acute lung injury in spontaneously breathing mice.
Experimental animal study.
Animal laboratory.
C57Bl/6 mice.
Mice were inoculated with the rodent pneumovirus, pneumonia virus of mice.
Pneumonia virus of mice-infected mice were studied for right and left ventricular function variables by high-field strength (7 Tesla) cardiac MRI at specific time points during the course of disease compared with baseline. One day before and at peak disease severity, pneumonia virus of mice-infected mice showed significant right and left ventricular systolic and diastolic volume changes, with a progressive decrease in stroke volume and ejection fraction. No evidence for viral myocarditis or viral presence in heart tissue was found.
These findings show adverse pulmonary-cardiac interaction in pneumovirus-induced acute lung injury, unrelated to direct virus-mediated effects on the heart.
在自主呼吸的小鼠肺炎病毒诱导的急性肺损伤中确定双心室心功能。
实验动物研究。
动物实验室。
C57Bl/6 小鼠。
用鼠肺炎病毒感染小鼠。
与基线相比，在疾病过程中的特定时间点，通过高场强（7 特斯拉）心脏 MRI 研究肺炎病毒感染的小鼠的右心室和左心室功能变量。在疾病严重程度高峰前一天和当天，肺炎病毒感染的小鼠出现明显的右心室和左心室收缩和舒张容积变化，伴有心搏量和射血分数逐渐降低。未发现病毒性心肌炎或心脏组织中的病毒存在。
这些发现表明肺炎病毒诱导的急性肺损伤中存在不利的肺-心相互作用，与病毒直接介导对心脏的影响无关。
