Marovic Danijela, Tarle Zrinka, Hiller Karl Anton, Müller Rainer, Ristic Mira, Rosentritt Martin, Skrtic Drago, Schmalz Gottfried
Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Gunduliceva 5, 10000, Zagreb, Croatia,
Clin Oral Investig. 2014 Apr;18(3):783-92. doi: 10.1007/s00784-013-1044-x. Epub 2013 Jul 19.
Experimental composite resins with amorphous calcium phosphate (ACP) have the potential to regenerate demineralized tooth structures. The aim of the study was to investigate the effect of the addition of silanized silica nanofillers to the ACP-based composites on their mechanical properties and the kinetics of calcium and phosphate release.
The test materials comprised 5 wt% (5-ACP) or 10 wt% (10-ACP) of silanized silica admixed to the 40 wt% ACP and 50 or 55 wt% resin. The ACP control (0-ACP) contained 40 wt% ACP and 60 wt% resin. Additionally, composite material CeramX (Dentsply, Germany) was included as control. Three-point bending test was performed to calculate flexural strength and modulus of elasticity. Inductively coupled plasma atomic emission spectroscopy was used for measurement of ion release. The micromorphology of calcium phosphate depositions on composite samples has been qualitatively evaluated using a scanning electron microscope. The results were analyzed using Mann-Whitney and Wilcoxon rank sum tests (α < 0.05).
Ion release was enhanced by the silica fillers, when compared to the 0-ACP. Although not statistically significant, flexural strength of 10-ACP was improved by 46 % compared to 0-ACP. Flexural modulus of 5-ACP was significantly higher than 0-ACP.
The admixture of silanized fillers seems to be a promising approach for the improvement of mechanical and remineralizing properties of ACP composite resins.
ACP-based composite resins with modified composition could serve as an effective remineralizing aid as base materials in restorative dental medicine.
含无定形磷酸钙（ACP）的实验性复合树脂具有使脱矿牙体组织再生的潜力。本研究旨在探讨向基于ACP的复合材料中添加硅烷化二氧化硅纳米填料对其机械性能以及钙和磷释放动力学的影响。
测试材料包括将5 wt%（5-ACP）或10 wt%（10-ACP）的硅烷化二氧化硅与40 wt%的ACP和50或55 wt%的树脂混合。ACP对照组（0-ACP）包含40 wt%的ACP和60 wt%的树脂。此外，还纳入了复合材料CeramX（德国登士柏公司）作为对照。进行三点弯曲试验以计算弯曲强度和弹性模量。采用电感耦合等离子体原子发射光谱法测量离子释放。使用扫描电子显微镜对复合样品上磷酸钙沉积物的微观形态进行定性评估。结果采用Mann-Whitney检验和Wilcoxon秩和检验进行分析（α < 0.05）。
与0-ACP相比，二氧化硅填料增强了离子释放。虽然无统计学意义，但10-ACP的弯曲强度比0-ACP提高了46%。5-ACP的弯曲模量显著高于0-ACP。
硅烷化填料的掺混似乎是改善ACP复合树脂机械性能和再矿化性能的一种有前景的方法。
具有改良成分的基于ACP的复合树脂可作为口腔修复医学中作为基础材料的有效再矿化辅助剂。
