Department of Endodontics and Restorative Dentistry, University of Zagreb, 10000 Zagreb, Croatia.
Department of Conservative and Preventive Dentistry, Centre for Dental Medicine, University of Zurich, 8032 Zurich, Switzerland.
Int J Mol Sci. 2022 Jul 25;23(15):8195. doi: 10.3390/ijms23158195.
We embedded copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) with antibacterial and ion-releasing properties into experimental dental composites and investigated the effect of Cu-MBGN on the polymerisation properties. We prepared seven composites with a BisGMA/TEGDMA (60/40) matrix and 65 wt.% total filler content, added Cu-MBGN or a combination of Cu-MBGN and silanised silica to the silanised barium glass base, and examined nine parameters: light transmittance, degree of conversion (DC), maximum polymerisation rate (R), time to reach R, linear shrinkage, shrinkage stress (PSS), maximum PSS rate, time to reach maximum PSS rate, and depth of cure. Cu-MBGN without silica accelerated polymerisation, reduced light transmission, and had the highest DC (58.8 ± 0.9%) and R (9.8 ± 0.2%/s), but lower shrinkage (3 ± 0.05%) and similar PSS (0.89 ± 0.07 MPa) versus the inert reference (0.83 ± 0.13 MPa). Combined Cu-MBGN and silica slowed the R and achieved a similar DC but resulted in higher shrinkage. However, using a combined 5 wt.% Cu-MBGN and silica, the PSS resembled that of the inert reference. The synergistic action of 5 wt.% Cu-MBGN and silanised silica in combination with silanised barium glass resulted in a material with the highest likelihood for dental applications in future.
我们将具有抗菌和离子释放性能的铜掺杂介孔生物活性玻璃纳米球（Cu-MBGN）嵌入到实验性牙科复合材料中，并研究了 Cu-MBGN 对聚合性能的影响。我们制备了七种具有 BisGMA/TEGDMA（60/40）基质和 65wt.%总填料含量的复合材料，在硅烷化钡玻璃基底中添加了 Cu-MBGN 或 Cu-MBGN 与硅烷化二氧化硅的混合物，并检查了九个参数：透光率、转化率（DC）、最大聚合速率（R）、达到 R 的时间、线性收缩率、收缩应力（PSS）、最大 PSS 速率、达到最大 PSS 速率的时间和固化深度。没有二氧化硅的 Cu-MBGN 加速了聚合，降低了透光率，具有最高的 DC（58.8±0.9%）和 R（9.8±0.2%/s），但收缩率（3±0.05%）和相似的 PSS（0.89±0.07 MPa）与惰性参考值（0.83±0.13 MPa）相比。Cu-MBGN 和二氧化硅的组合减缓了 R 的速度并实现了相似的 DC，但导致了更高的收缩率。然而，使用 5wt.%的 Cu-MBGN 和二氧化硅的组合，PSS 类似于惰性参考值。5wt.%的 Cu-MBGN 和硅烷化二氧化硅与硅烷化钡玻璃的协同作用产生了一种在未来牙科应用中最有可能的材料。
