Advenier C, Mallard B, Santais M C, Ruff F
Agents Actions. 1979 Dec;9(5-6):467-73. doi: 10.1007/BF01968112.
The effects of metiamide and of four H1 receptor blocking agents (mepyramine, promethazine, clemastine and ketotifene) on anaphylactic reaction were studied in the guinea-pig. The H1 blockers conferred partial protection which shows that with the experimental protocol utilized (challenge injection with high doses of antigen), histamine plays a lesser role than other mediators released or synthesized. Metiamide (30.0 mg/kg i.v.) noticeably enhanced the increase in pulmonary resistance observed during anaphylactic reaction and reduced the protective effect of the H1 antagonists on this parameter and on histamine release. These effects might be explained by an inhibition - at least partial - of the negative feed-back mechanism through which histamine controls its own release, or by a specific action of metiamide in high doses. The transient tachycardia initially observed in anaphylactic shock is partly related to stimulation of cardiac H2 receptors by the histamine released, since it is suppressed by metiamide.
在豚鼠身上研究了甲硫米特和四种H1受体阻断剂（甲氧苄二胺、异丙嗪、氯马斯汀和酮替芬）对过敏反应的影响。H1受体阻断剂提供了部分保护，这表明在所采用的实验方案（高剂量抗原激发注射）中，组胺所起的作用比其他释放或合成的介质要小。甲硫米特（静脉注射30.0mg/kg）显著增强了过敏反应期间观察到的肺阻力增加，并降低了H1拮抗剂对该参数和组胺释放的保护作用。这些作用可能是由于至少部分抑制了组胺控制自身释放的负反馈机制，或者是由于高剂量甲硫米特的特定作用。过敏休克最初观察到的短暂性心动过速部分与释放的组胺对心脏H2受体的刺激有关，因为它被甲硫米特所抑制。
