Oncology Unit, Third Department of Medicine, Athens University School of Medicine, Sotiria General Hospital, Building Z, 152 Mesogion Avenue, 115 27 Athens, Greece.
Cancer Treat Rev. 2014 Feb;40(1):22-30. doi: 10.1016/j.ctrv.2013.06.005. Epub 2013 Jul 16.
Adipose tissue secretes numerous bioactive peptides, collectively termed "adipocytokines" or "adipokines". Adipokines act in a paracrine, autocrine, or endocrine manner and regulate several physiological and pathological processes. Increasing evidence indicates that adipokines are implicated also in several malignancies, including lung cancer as well.
The aim of this study is to summarize data concerning adipokines in lung cancer pathogenesis, prognosis and survival; the role of adipokines in lung cancer cachexia is also examined.
A systematic literature search was performed in the electronic database of Medline. Several studies and review articles met the inclusion criteria.
Leptin and adiponectin are the best studied adipokines. The majority of the relevant studies has investigated the potential correlations mainly between leptin, adiponectin, and sometimes also resistin, and nutritional status, systemic inflammation of lung cancer or lung cancer cachexia and have also assessed their prognostic significance. Few other studies have studied genetic variations in leptin, leptin receptor and adiponectin genes and their association with lung cancer susceptibility and prognosis. The ongoing list of adipokines associated with lung cancer also includes resistin, chemerin, and visfatin.
Increasing evidence points to the involvement of certain adipocytokines in lung cancer development, progression and prognosis. No conclusive evidence exists so far with regards to the role of adipocytokines in lung cancer cachexia. Future, longitudinal studies are warranted in order to clarify the role of adipocytokines in lung cancer and also uncover adipocytokines as novel therapeutic targets.
脂肪组织分泌许多生物活性肽，统称为“脂肪细胞因子”或“脂肪因子”。脂肪因子以旁分泌、自分泌或内分泌的方式发挥作用，调节多种生理和病理过程。越来越多的证据表明，脂肪因子也与多种恶性肿瘤有关，包括肺癌。
本研究旨在总结有关脂肪因子在肺癌发病机制、预后和生存中的数据；还研究了脂肪因子在肺癌恶病质中的作用。
在 Medline 电子数据库中进行了系统的文献检索。符合纳入标准的有几项研究和综述文章。
瘦素和脂联素是研究最多的脂肪因子。大多数相关研究主要调查了瘦素、脂联素，有时还有抵抗素，与营养状况、肺癌的全身炎症或肺癌恶病质之间的潜在相关性，并评估了它们的预后意义。还有一些其他研究研究了瘦素、瘦素受体和脂联素基因的遗传变异及其与肺癌易感性和预后的关系。与肺癌相关的正在进行的脂肪因子列表还包括抵抗素、趋化素和内脂素。
越来越多的证据表明某些脂肪细胞因子参与了肺癌的发生、发展和预后。目前尚无关于脂肪因子在肺癌恶病质中的作用的明确证据。未来需要进行纵向研究，以阐明脂肪因子在肺癌中的作用，并揭示脂肪因子作为新的治疗靶点。
