Querido L, Haspels A A
Vrelinghuis Clinic, Utrecht, The Netherlands.
Contraception. 1990 Jul;42(1):43-9. doi: 10.1016/0010-7824(90)90091-9.
The use of gemeprost (16,16-dimethyl-trans-delta 2-PGE1 methyl ester) vaginal pessaries for the termination of pregnancy in the late second trimester has been investigated in an open single-center study. Of 56 nulliparous women between 18 and 22 weeks amenorrhoea, 33 (58.9%) aborted after the administration of 1 mg gemeprost pessaries; 5 women did abort after 3 doses, 10 after 4 doses and 18 after 5 doses. There was no statistical correlation between gestational age and abortion. The mean induction-abortion interval was 15.2 hrs (range 8.5-20.3 hrs). There were no serious complications. The safe induction of therapeutic abortion in 58.9% of women using vaginal gemeprost pessaries alone offers an acceptable alternative to surgical evacuation in the late second trimester but should not be started without the possibility to terminate the procedure by dilatation and evacuation (D + E).
在一项开放性单中心研究中，对使用吉美前列素（16,16 - 二甲基 - 反式 - Δ2 - PGE1甲酯）阴道栓剂终止妊娠中期晚期妊娠进行了研究。在56名妊娠18至22周的未产妇中，33名（58.9%）在给予1毫克吉美前列素栓剂后流产；5名妇女在3剂后流产，10名在4剂后流产，18名在5剂后流产。孕周与流产之间无统计学相关性。引产至流产的平均间隔时间为15.2小时（范围8.5 - 20.3小时）。无严重并发症。仅使用阴道吉美前列素栓剂可使58.9%的妇女安全引产，这为妊娠中期晚期手术清宫提供了一种可接受的替代方法，但在没有通过扩张和清宫（D + E）终止手术的可能性时不应开始使用。
