Cameron I T, Michie A F, Baird D T
Department of Obstetrics and Gynaecology, University of Edinburgh, Scotland.
Prostaglandins. 1987 Jul;34(1):111-7. doi: 10.1016/0090-6980(87)90268-1.
The use of gemeprost (16,16 dimethyl-trans-delta 2-PGE1 methyl ester) vaginal pessaries for the termination of pregnancy in the early second trimester has been further investigated. Of 113 women between 12 and 16 weeks gestation, 93 (82%) aborted within 24 hours of the administration of 4.4 +/- 0.1 1 mg gemeprost pessaries. The mean induction-abortion interval was 881 +/- 31 minutes. Successful abortion was achieved in 16 of the remaining 20 women after a second course of gemeprost pessaries without the need for oxytocin supplementation. There were no serious complications. Crampy abdominal pain and vaginal bleeding started after 275 and 756 minutes respectively. Twenty-two (19%) patients did not require pain relief during treatment, but 90 (80%) required parenteral opiates. Vomiting and diarrhoea occurred in 16 (14%) and 23 (20%) cases respectively. The safe induction of therapeutic abortion in 96% of women using vaginal prostaglandin alone offers an acceptable alternative to surgical evacuation in the early second trimester.
已对使用吉美前列素（16,16 - 二甲基 - 反式 - δ2 - PGE1甲酯）阴道栓剂在孕中期早期终止妊娠进行了进一步研究。在113名妊娠12至16周的妇女中，93名（82%）在使用4.4±0.1毫克吉美前列素栓剂给药后24小时内流产。平均引产 - 流产间隔为881±31分钟。其余20名妇女中有16名在第二疗程使用吉美前列素栓剂后成功流产，无需补充催产素。无严重并发症发生。痉挛性腹痛和阴道出血分别在275分钟和756分钟后开始。22名（19%）患者在治疗期间不需要止痛，但90名（80%）需要胃肠外使用阿片类药物。呕吐和腹泻分别发生在16例（14%）和23例（20%）中。仅使用阴道前列腺素使96%的妇女安全引产，为孕中期早期手术清宫提供了一种可接受的替代方法。
