扩展细胞外酶体系范例：模块化梭菌热纤维梭菌细胞外酶体系丝氨酸蛋白酶抑制剂 PinA 是一种广谱的枯草杆菌蛋白酶样蛋白酶抑制剂。
Extending the cellulosome paradigm: the modular Clostridium thermocellum cellulosomal serpin PinA is a broad-spectrum inhibitor of subtilisin-like proteases.
机构信息
CSIRO Animal, Food and Health Sciences, Queensland Biosciences Precinct, St. Lucia, Queensland, Australia.
出版信息
Appl Environ Microbiol. 2013 Oct;79(19):6173-5. doi: 10.1128/AEM.01912-13. Epub 2013 Jul 19.
Abstract
Clostridium thermocellum encodes a cellulosomal, modular, and thermostable serine protease inhibitor (serpin), PinA. PinA stability but not inhibitory activity is affected by the Fn(III) and Doc(I) domains, and PinA is a broad inhibitor of subtilisin-like proteases and may play a key role in protecting the cellulosome from protease attack.
摘要
热纤梭菌编码一种细胞外酶解纤维簇状的、模块化的和热稳定的丝氨酸蛋白酶抑制剂（丝氨酸蛋白酶抑制剂），PinA。PinA 的稳定性而非抑制活性受 Fn（III）和 Doc（I）结构域的影响，PinA 是枯草杆菌蛋白酶样蛋白酶的广谱抑制剂，可能在保护细胞外酶解纤维簇免受蛋白酶攻击方面发挥关键作用。
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