Fernández-Teruel A, Escorihuela R M, Boix F, Tobeña A
Department of Pharmacology and Psychiatry, School of Medicine, Autonomous University of Barcelona, Spain.
Eur J Pharmacol. 1990 May 31;181(1-2):35-41. doi: 10.1016/0014-2999(90)90242-x.
The aim was to find whether the chloride channel blocker, picrotoxin, at subconvulsant doses could affect the activity of imipramine or desipramine in the 'forced swimming' test with rats. It was found that picrotoxin enhanced the anti-immobility effects of imipramine and desipramine whereas open field activity remained unaffected or was even decreased by the same treatments. The results seem consistent with recent reports showing direct interactions between several antidepressant drugs and the GABAA receptor/benzodiazepine receptor/chloride ionophore complex (GABAA/benzodiazepine/Cl complex). The results also conform with the hypothesis that a reduction in the functionality of this complex could be related to the clinical effects of antidepressant drugs.
目的是探究在亚惊厥剂量下，氯化物通道阻滞剂印防己毒素是否会影响丙咪嗪或地昔帕明在大鼠“强迫游泳”试验中的活性。结果发现，印防己毒素增强了丙咪嗪和地昔帕明的抗不动效应，而旷场活动不受影响，甚至在相同处理下有所降低。这些结果似乎与近期的报道一致，这些报道表明几种抗抑郁药物与GABAA受体/苯二氮䓬受体/氯离子载体复合物（GABAA/苯二氮䓬/Cl复合物）之间存在直接相互作用。这些结果也符合这样一种假设，即该复合物功能的降低可能与抗抑郁药物的临床效果有关。
