Gravina A, Domenici L, Berardi N, Galli L, Maffei L
Istituto di Neurofisiologia del CNR, Pisa, Italy.
Exp Brain Res. 1990;80(3):631-4. doi: 10.1007/BF00228004.
We have investigated the effectiveness of embryonal tectal tissue transplants in preserving the physiological activity of lesioned ganglion cells by recording the visual responses from the adult rat retina after section of the optic nerve, with or without transplants of embryonal nervous tissue on the stump. We have found that transplant of embryonal nervous tissue at the level of the optic nerve section has dramatic effects in preserving visual retinal responses to patterned stimuli for times as long as five months after surgery. By this time retinal responses to patterned stimuli have almost completely disappeared in control animals with optic nerve section alone.
我们通过记录视神经切断术后成年大鼠视网膜的视觉反应，研究了胚胎顶盖组织移植在保留受损神经节细胞生理活性方面的有效性，视神经切断术后残端有无胚胎神经组织移植。我们发现，在视神经切断水平移植胚胎神经组织对保留视网膜对图案刺激的视觉反应具有显著效果，术后长达五个月仍有反应。而此时，仅进行视神经切断的对照动物中，视网膜对图案刺激的反应几乎完全消失。
