Keirstead S A, Rasminsky M, Fukuda Y, Carter D A, Aguayo A J, Vidal-Sanz M
Neurosciences Unit, Montreal General Hospital, Quebec, Canada.
Science. 1989 Oct 13;246(4927):255-7. doi: 10.1126/science.2799387.
Autologous peripheral nerve grafts were used to permit and direct the regrowth of retinal ganglion cell axons from the eye to the ipsilateral superior colliculus of adult hamsters in which the optic nerves had been transected within the orbit. Extracellular recordings in the superior colliculus 15 to 18 weeks after graft insertion revealed excitatory and inhibitory postsynaptic responses to visual stimulation. The finding of light-induced responses in neurons in the superficial layers of the superior colliculus close to the graft indicates that axons regenerating from axotomized retinal ganglion cells can establish electrophysiologically functional synapses with neurons in the superior colliculus of these adult mammals.
自体周围神经移植物被用于使成年仓鼠眼眶内视神经被横断后视网膜神经节细胞轴突从眼睛向同侧上丘生长并引导其生长。移植后15至18周对上丘进行细胞外记录，发现对视觉刺激有兴奋性和抑制性突触后反应。在上丘靠近移植物的表层神经元中发现光诱导反应，这表明从轴突切断的视网膜神经节细胞再生的轴突能够与这些成年哺乳动物上丘中的神经元建立电生理功能突触。
