Nelson H, Mandiyan S, Nelson N
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.
FEBS Lett. 1990 Aug 20;269(1):181-4. doi: 10.1016/0014-5793(90)81149-i.
A cDNA clone encoding a transporter for the neurotransmitter gamma-aminobutyric acid in human brain was cloned and sequenced. The cDNA contains an open reading frame encoding a hydrophobic protein of 599 amino acids with a calculated molecular weight of 67022 Da. Hydropathy analysis revealed twelve potential transmembrane segments. The human protein is highly homologous to the protein from rat brain. Northern hybridization demonstrated a ubiquitous distribution of the transporter in various parts of the brain.
