Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 De Soto St., Pittsburgh, PA, 15261, USA,
Int J Public Health. 2013 Oct;58(5):695-705. doi: 10.1007/s00038-013-0491-0. Epub 2013 Jul 23.
Assess the association between 8-hydroxy-2'-deoxyguanosine (8OHdG) levels and particulate matter air pollution in non-occupational exposure groups from peer-reviewed literature.
Ovid Medline and PubMed were used to search for all peer-reviewed articles published between 1946 and May 2013. Keywords included particulate matter, air pollution, deoxyguanosine, 8-hydroxy-2'-deoxyguanosine, and known abbreviations. Seven English, non-occupational exposure, human subject studies were evaluated.
Of the two studies involving children one found significant positive associations between exposure to particulate matter air pollution and 8OHdG. Investigations into non-occupationally exposed adults were mixed. The lone double-blind crossover study found no relationship between diesel exhaust exposure and 8OHdG. Two out of three panel studies and one cohort study found significant associations between 8OHdG and classes of particles and for various lags.
Analyses accounting for particle composition and lags between exposure and physiological responses had the strongest significant associations. Results are not conclusive due to the inconsistency in study designs, small sample sizes, and differences in exposure assessment techniques. Consistent methodology with representative populations including women and other non-occupationally exposed groups are recommended.
评估同行评审文献中非职业暴露人群中 8-羟基-2'-脱氧鸟苷（8OHdG）水平与颗粒物空气污染之间的关联。
使用 Ovid Medline 和 PubMed 搜索了 1946 年至 2013 年 5 月期间发表的所有同行评审文章。关键词包括颗粒物、空气污染、脱氧鸟苷、8-羟基-2'-脱氧鸟苷和已知缩写。评估了 7 项英文、非职业暴露、人体研究。
两项涉及儿童的研究中，有一项发现颗粒物空气污染与 8OHdG 之间存在显著正相关。对非职业暴露成年人的调查结果不一。唯一的双盲交叉研究发现，柴油机废气暴露与 8OHdG 之间没有关系。三项面板研究中有两项和一项队列研究发现 8OHdG 与颗粒类别之间存在显著关联，并且存在不同的滞后时间。
分析考虑了颗粒成分和暴露与生理反应之间的滞后时间，具有最强的显著关联。由于研究设计、样本量小以及暴露评估技术的差异，结果不一致，因此结论尚不确定。建议采用一致的方法，纳入具有代表性的人群，包括妇女和其他非职业暴露人群。
