Food and Nutrition Unit, IRCCS San Raffaele Pisana, Rome, Italy.
Biomarkers. 2010 Sep;15(6):538-45. doi: 10.3109/1354750X.2010.493974.
Oxidative stress is one of the mechanisms through which traffic-related air pollution causes adverse effects on human health. The urinary excretion of 8-oxo-7,8-dihydro-2-deoxyguanosine (8oxodG) has often been used as a biomarker to evaluate the effect of air pollution on subjects occupationally exposed. We used a meta-analysis to evaluate the effect of traffic air pollution on urinary 8oxodG levels in healthy workers. We observed higher urinary 8oxodG levels in non-smoking exposed subjects compared with smokers. This difference was clearer when an HPLC assay was used. These results show that urinary 8oxodG can be used as a biomarker to evaluate the pro-oxidant effects of vehicle exhaust emissions on DNA in exposed workers.
氧化应激是交通相关空气污染对人类健康造成不良影响的机制之一。8-氧代-7,8-二氢-2-脱氧鸟苷（8oxodG）的尿排泄通常被用作评估空气污染对职业暴露人群影响的生物标志物。我们使用荟萃分析来评估交通空气污染对健康工人尿液 8oxodG 水平的影响。我们观察到，与吸烟者相比，非吸烟暴露人群的尿液 8oxodG 水平更高。当使用 HPLC 测定法时，这种差异更为明显。这些结果表明，尿液 8oxodG 可作为生物标志物，用于评估车辆废气排放物对暴露工人 DNA 的促氧化作用。
