把握时机：细胞分裂中 Rho1 和 Cdc42 GTPases 的精确 ON/OFF 开关。

Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis.

机构信息

Temasek Life Sciences Laboratory, 2 Department of Biological Sciences, and 3 Mechanobiology Institute, National University of Singapore, Singapore 117604.

出版信息

J Cell Biol. 2013 Jul 22;202(2):187-9. doi: 10.1083/jcb.201306152.

DOI:10.1083/jcb.201306152

PMID:23878271

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3718978/

Abstract

In many eukaryotes, cytokinesis requires an actomyosin contractile ring that is crucial for cell constriction and new membrane organization. Two studies in this issue (Onishi et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201302001 and Atkins et al. 2013. J. Cell Biol. http://dx.doi.org.10.1083/jcb.201301090) establish that precise activation and/or inactivation of Rho1 and Cdc42 GTPases is important for the correct order and successful completion of events downstream of actomyosin ring constriction in budding yeast.

摘要

在许多真核生物中，胞质分裂需要肌动球蛋白收缩环，这对于细胞缢缩和新膜的组织至关重要。本期的两项研究（Onishi 等人，2013，《细胞生物学杂志》，http://dx.doi.org/10.1083/jcb.201302001；以及 Atkins 等人，2013，《细胞生物学杂志》，http://dx.doi.org/10.1083/jcb.201301090）表明，Rho1 和 Cdc42 GTPases 的精确激活和/或失活对于出芽酵母中肌动球蛋白收缩环收缩下游事件的正确顺序和成功完成非常重要。