自闭症患者的血浆铜和锌浓度与特定症状的严重程度相关。
Plasma copper and zinc concentration in individuals with autism correlate with selected symptom severity.
作者信息
Russo Anthony J, Bazin Andrea P, Bigega Richard, Carlson Robert S, Cole Martin G, Contreras Dilenia C, Galvin Matthew B, Gaydorus Sayde S, Holik Sierra D, Jenkins Gavin P, Jones Brandon M, Languell Penelope A, Lyman Padraic J, March Kareem P, Meuer Katie A, Peterson Serena R, Piedmonte Matthew T, Quinn Michael G, Smaranda Nicole C, Steves Patrick L, Taylor Heather P, Waddingham Teagan E, Warren Janine S
机构信息
Hartwick College, Oneonta, NY 13820.
出版信息
Nutr Metab Insights. 2012 Feb 28;5:41-7. doi: 10.4137/NMI.S8761. Print 2012.
AIM
To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity.
SUBJECTS AND METHODS
Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity of 19 symptoms.
RESULTS
Autistic individuals had elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. There was a correlation between Cu/Zn and expressive language, receptive language, focus attention, hyperactivity, fine motor skills, gross motor skills and Tip Toeing. There was a negative correlation between plasma zinc concentration and hyperactivity, and fine motor skills severity.
DISCUSSION
These results suggest an association between plasma Cu/Zn and severity of symptoms associated with autism.
目的
评估自闭症患者的血浆锌和铜浓度，并将这些水平与症状严重程度相关联。
对象与方法
采用电感耦合等离子体质谱法对102名自闭症患者和18名神经典型对照者的血浆进行锌和铜检测。分析铜、锌水平及铜/锌比值与19种症状严重程度的可能相关性。
结果
与神经典型对照者相比，自闭症患者血浆铜和铜/锌水平升高，血浆锌水平较低，但无显著降低。铜/锌与表达性语言、接受性语言、注意力集中、多动、精细运动技能、粗大运动技能和踮脚尖之间存在相关性。血浆锌浓度与多动及精细运动技能严重程度呈负相关。
讨论
这些结果表明血浆铜/锌与自闭症相关症状的严重程度之间存在关联。
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