苯二氮䓬类化合物对脑胺代谢的影响。
Effect of benzodiazepine compounds on brain amine metabolism.
作者信息
Dominic J A, Sinha A K, Barchas J D
出版信息
Eur J Pharmacol. 1975 May;32(1):124-7. doi: 10.1016/0014-2999(75)90332-5.
PMID:238864
Abstract
In mice, chlordiazepoxide, diazepam and flurazepam reduced 5-HT synthesis and metabolism in the teldiencephalon following an i.v. injection of 3H-tryptophan. Only diazepam produced a significant effect in the brainstem. The steady state level of brain 5-HT or of tryptophan was not altered by any of the drugs. Chlordiazepoxide and diazepam, but not flurazepam, decreased the rate of norepinephrine loss from the brain following inhibition of synthesis with alpha-methyltyrosine.
摘要
在小鼠中，静脉注射3H-色氨酸后，氯氮卓、地西泮和氟西泮降低了端脑5-羟色胺的合成和代谢。只有地西泮对脑干产生显著影响。任何一种药物均未改变脑5-羟色胺或色氨酸的稳态水平。在用α-甲基酪氨酸抑制去甲肾上腺素合成后，氯氮卓和地西泮（而非氟西泮）降低了脑中去甲肾上腺素的丢失率。
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