Department of Molecular Biotechnology and Health Sciences-Center for Molecular Biotechnology, University of Torino, Torino, Italy.
Oncogene. 2014 Jun 12;33(24):3083-90. doi: 10.1038/onc.2013.265. Epub 2013 Jul 29.
Over the past decade the phosphoinositide-3 kinase (PI3K) signaling pathway emerged as an important player for tumor initiation and growth and, currently, PI3K inhibition constitutes a promising therapeutic approach for solid and hematological tumors. Beside its role in tumor cell evolution, PI3K signaling also provides integral functions for noncancerous cells that reside in healthy tissues surrounding the tumor, also referred as tumor microenvironment (TME). This review will address how PI3K signaling participates to the tumorigenic process and discuss the interaction between tumor cells and the surrounding TME, with particular focus on the role of PI3Ks in tumor-associated immune responses, tumor angiogenesis and metastasis formation.
在过去的十年中，磷酸肌醇 3 激酶（PI3K）信号通路已成为肿瘤发生和生长的重要参与者，目前，PI3K 抑制已成为实体瘤和血液系统肿瘤的一种有前途的治疗方法。除了在肿瘤细胞进化中的作用外，PI3K 信号还为肿瘤周围健康组织中的非癌细胞提供了重要功能，也称为肿瘤微环境（TME）。本文将讨论 PI3K 信号如何参与肿瘤发生过程，并讨论肿瘤细胞与周围 TME 之间的相互作用，特别关注 PI3Ks 在肿瘤相关免疫反应、肿瘤血管生成和转移形成中的作用。
