Public Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
PLoS One. 2013 Jul 22;8(7):e68605. doi: 10.1371/journal.pone.0068605. Print 2013.
To study 1-year effectiveness of an intensive, culturally targeted lifestyle intervention in general practice for weight status and metabolic profile of South-Asians at risk of type 2 diabetes.
536 South-Asians at risk of type 2 diabetes were randomized to an intervention (n = 283) or control (n = 253) group. The intervention, which was targeted culturally to the South-Asian population, consisted of individual lifestyle counselling, a family session, cooking classes, and supervised physical activity programme. All components of the intervention were carried out by professionals as part of their daily clinical practice. The control group received generic lifestyle advice. Change in weight status and metabolic profile were assessed after 1 year.
After 1 year, 201 participants were lost to follow-up. Remaining participants in intervention (n = 177) and control (n = 158) group had similar baseline characteristics. Weight loss in the intervention group was 0.2±3.3 kg, weight gain in the control group was 0.4±3.1 kg (p = 0.08). Changes in other weight-related measurements did not differ significantly between groups. Furthermore, there were no differences between groups in changes of metabolic profile. All results remained similar after repeating analyses in a multiple imputed dataset.
An intensive, culturally targeted, lifestyle intervention of 1 year did not improve weight status and metabolic profile of South-Asians at risk of type 2 diabetes. The laborious recruitment, high drop-out, and lack of effectiveness emphasise the difficulty of realising health benefits in practice and suggest that this strategy might not be the optimal approach for this population.
Nederlands Trial Register NTR1499.
研究在初级保健中针对南亚人进行强化、文化针对性的生活方式干预对 2 型糖尿病风险的南亚人体重状况和代谢特征的 1 年效果。
将 536 名有 2 型糖尿病风险的南亚人随机分为干预组（n=283）和对照组（n=253）。针对南亚人群的文化特点，该干预措施包括个体生活方式咨询、家庭会议、烹饪课程和监督体育活动方案。干预的所有组成部分均由专业人员在日常临床实践中进行。对照组接受一般性生活方式建议。在 1 年后评估体重状况和代谢特征的变化。
1 年后，有 201 名参与者失访。干预组（n=177）和对照组（n=158）的其余参与者具有相似的基线特征。干预组的体重减轻量为 0.2±3.3kg，对照组的体重增加量为 0.4±3.1kg（p=0.08）。两组之间其他与体重相关的测量值的变化无显著差异。此外，两组之间代谢特征的变化也没有差异。在重复分析多重插补数据集后，所有结果仍然相似。
为期 1 年的强化、文化针对性的生活方式干预并未改善 2 型糖尿病风险的南亚人的体重状况和代谢特征。费力的招募、高辍学率和缺乏效果强调了在实践中实现健康益处的困难，并表明这种策略可能不是该人群的最佳方法。
荷兰试验注册处 NTR1499。
