TNF-α 启动子区域多态性影响中国南方人群乙型肝炎病毒的清除。
TNF-alpha promoter region polymorphisms affect HBV virus clearance in southern Chinese.
机构信息
Operating Room, The Second Hospital of Nanchang, 90 Bayidadao Road, Nanchang, JiangXi 330003, China; NPFPC Laboratory of Contraception and Devices, Shanghai Institute of Planned Parenthood Research, 2140 Xietu Road, Shanghai 200032, China.
出版信息
Clin Chim Acta. 2013 Oct 21;425:90-2. doi: 10.1016/j.cca.2013.07.015. Epub 2013 Jul 26.
BACKGROUND
There are many cytokines, including TNF-α, TGFβ, PGF, and other factors contributing towards fibrogenesis, that play a role in the control of HBV infection. Among these, TNF-α is the most important cytokine in host immune response to viral infection. This study aimed to determine whether differences in the promoter region of the TNF-α gene may alter the outcomes of HBV infection.
METHODS
Two polymorphisms of tumor necrosis factor-α (TNF-α) gene, -308 G/A (rs1800629) and -863 C/A (rs1800630), were analyzed by DNA sequence in the case-control sample using 171 chronic HBV-infected patients and 227 recovered HBV-infected controls. All subjects were unrelated southern Han Chinese.
RESULTS
For TNF-α-308, healthy controls compared to HBV infection have a significantly higher allele A and GA genotype frequency. For TNF-α-863, no significant differences in allele or genotype frequencies between the case groups and the control group were observed.
CONCLUSIONS
This study provides evidence of a positive association between HBV clearance and TNF-α-308A.
背景
有许多细胞因子，包括 TNF-α、TGFβ、PGF 等，参与肝纤维化的形成，它们在控制 HBV 感染中发挥作用。其中，TNF-α 是宿主对病毒感染免疫反应中最重要的细胞因子。本研究旨在确定 TNF-α 基因启动子区域的差异是否会改变 HBV 感染的结果。
方法
通过 DNA 序列分析，在病例对照样本中分析了肿瘤坏死因子-α（TNF-α）基因的两个多态性，-308 G/A（rs1800629）和-863 C/A（rs1800630），该样本包括 171 名慢性 HBV 感染患者和 227 名已恢复 HBV 感染的对照。所有受试者均为无血缘关系的南方汉族人。
结果
对于 TNF-α-308，与 HBV 感染相比，健康对照组的等位基因 A 和 GA 基因型频率明显更高。对于 TNF-α-863，病例组和对照组之间的等位基因或基因型频率没有显著差异。
结论
本研究提供了 HBV 清除与 TNF-α-308A 之间存在正相关的证据。
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