磷脂代谢及上游调控因子变异与非小细胞肺癌易感性
Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility.
机构信息
Division of Translational Oncology, Health Research Institute and University Hospital Fundación Jiménez Díaz, Madrid, Spain,
出版信息
Clin Transl Oncol. 2014 Jan;16(1):107-12. doi: 10.1007/s12094-013-1080-7. Epub 2013 Jul 30.
AIM
The relevance of the cytidine diphosphate-choline and Rho GTPases pathways in the pathogenesis of cancer has been previously demonstrated. We investigate by a case-control association study if genetics variants in these pathways are associated with risk of developing lung cancer.
METHODS
Thirty-seven tag SNPs were evaluated as risk factor of NSCLC in 897 cases and 904 controls.
RESULTS
Six SNPs were nominally associated with lung cancer risk, which were not significant after the Bonferroni correction for multiple comparisons. No association was observed with the remaining 31 analyzed SNPs, neither it was found significant in haplotype frequencies.
CONCLUSIONS
Although the implication of the two pathways investigated in our study in carcinogenesis is well established, our null results suggest that common genetic variants in CDP-choline and Rho GTPases-related genes are not risk factors for lung cancer.
目的
先前已经证明，胞苷二磷酸胆碱和 Rho GTPases 途径与癌症的发病机制有关。我们通过病例对照关联研究来调查这些途径中的遗传变异是否与肺癌的发病风险相关。
方法
在 897 例病例和 904 例对照中，评估了 37 个标记 SNP 是否为非小细胞肺癌的危险因素。
结果
有 6 个 SNP 与肺癌风险呈显著相关，但在经过多重比较的 Bonferroni 校正后，这些关联不再显著。对于其余 31 个分析的 SNP，没有观察到相关性，也没有发现单倍型频率有显著差异。
结论
尽管我们研究中所涉及的两条途径在致癌作用中的意义已经得到很好的证实，但我们的阴性结果表明，CDP-胆碱和 Rho GTPases 相关基因中的常见遗传变异不是肺癌的危险因素。
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