从微克到克：甲磺酸艾瑞布林的规模化合成。
From micrograms to grams: scale-up synthesis of eribulin mesylate.
机构信息
Eisai Inc., Andover, MA, USA.
出版信息
Nat Prod Rep. 2013 Sep;30(9):1158-64. doi: 10.1039/c3np70051h. Epub 2013 Jul 30.
PMID:23896896
Abstract
The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon-carbon bond and macrocyclic ring closure through an intramolecular Nozaki-Hiyama-Kishi reaction.
摘要
本文描述了从微克到多克规模的甲磺酸艾日布林的合成。关键的偶联反应包括通过分子内 Nozaki-Hiyama-Kishi 反应形成 C30a 到 C1 碳-碳键和大环环化。
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