Németh Viktória, Oldal Miklós, Madai Mónika, Horváth Győző, Kemenesi Gábor, Dallos Bianka, Bányai Krisztián, Jakab Ferenc
Virological Research Group, János Szentágothai Research Center, University of Pécs, Ifjúság út 20, Pecs, 7624, Hungary.
Virus Genes. 2013 Dec;47(3):546-9. doi: 10.1007/s11262-013-0963-6. Epub 2013 Jul 30.
Among the Hantavirus genus, Saaremaa virus (SAAV) has been the subject of taxonomical debates. While the International Committee on Taxonomy of Viruses declares SAAV as a distinct species, several European hantavirus experts proposed that SAAV is in fact a genotype of Dobrava-Belgrade virus (DOBV). In the present study we performed S-segment-based phylogenetic analysis of eight DOBV strains identified in rodents in Hungary and Northern Croatia. These new sequences considerably increase the number of complete nucleoprotein gene sequences deposited in the NCBI database. Our phylogenetic analysis clearly support the taxonomical nomenclature recently proposed for DOBV, i.e., genotypes such as Dobrava, Saaremaa, Kurkino, and Sochi should indeed be classified within the DOBV hantavirus species. Moreover, we found that only the Dobrava and Kurkino genotypes of DOBV species are circulating in Hungary while currently there is no evidence for the presence of Saaremaa genotype.
在汉坦病毒属中，萨雷马病毒（SAAV）一直是分类学争论的主题。虽然国际病毒分类委员会将SAAV宣布为一个独特的物种，但几位欧洲汉坦病毒专家提出，SAAV实际上是多布拉瓦-贝尔格莱德病毒（DOBV）的一个基因型。在本研究中，我们对在匈牙利和克罗地亚北部啮齿动物中鉴定出的8株DOBV菌株进行了基于S片段的系统发育分析。这些新序列大大增加了NCBI数据库中 deposited的完整核蛋白基因序列的数量。我们的系统发育分析明确支持最近为DOBV提出的分类命名法，即多布拉瓦、萨雷马、库尔基诺和索契等基因型确实应归类于DOBV汉坦病毒物种。此外，我们发现匈牙利仅流行DOBV物种的多布拉瓦和库尔基诺基因型，而目前没有证据表明存在萨雷马基因型。
