Department of Pathology and Laboratory Medicine, The Brooklyn Hospital Center, Brooklyn, New York 11201, USA.
Arch Pathol Lab Med. 2013 Aug;137(8):1152-4. doi: 10.5858/arpa.2012-0294-RS.
Primary effusion lymphoma is a large cell non-Hodgkin lymphoma localized predominantly in body cavities and occasionally in extracavitary regions. It presents with characteristic lymphomatous effusions in the absence of solid tumor masses, and pleural, peritoneal, and pericardial spaces are most often involved. It is typically associated with human herpesvirus 8 infection in immunocompromised individuals, in the setting of human immunodeficiency virus infection, organ transplantation, or in rare cases advanced age. Histologically, primary effusion lymphoma is characterized by atypical lymphoid cells of B-cell lineage with large nuclei and prominent nucleoli. Demonstration of human herpesvirus 8 latent antigens is required for diagnosis, and treatment modalities are limited at this time. In this review, we aim to summarize clinicopathologic features of this rare and unique entity.
原发性渗出性淋巴瘤是一种主要局限于体腔、偶尔也局限于腔外部位的大细胞非霍奇金淋巴瘤。它以无实体瘤的特征性淋巴瘤性渗出为表现，最常累及胸膜、腹膜和心包腔。它通常与免疫功能低下个体中的人类疱疹病毒 8 感染、人类免疫缺陷病毒感染、器官移植或罕见的高龄相关。组织学上，原发性渗出性淋巴瘤的特征为具有大核和显著核仁的 B 细胞谱系的异型淋巴细胞。诊断需要证明存在人类疱疹病毒 8 潜伏抗原，而目前的治疗方式有限。在这篇综述中，我们旨在总结这种罕见而独特实体的临床病理特征。
