透明质酸水凝胶支架中细胞-基质相互作用的设计
Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds.
作者信息
Lam Jonathan, Truong Norman F, Segura Tatiana
机构信息
Bioengineering Department, Los Angeles CA 90095.
Chemical and Biomolecular Engineering Department, Los Angeles CA 90095.
出版信息
Acta Biomater. 2014 Apr;10(4):1571-1580. doi: 10.1016/j.actbio.2013.07.025. Epub 2013 Jul 27.
Abstract
The design of hyaluronic acid (HA)-based hydrogel scaffolds to elicit highly controlled and tunable cell response and behavior is a major field of interest in developing tissue engineering and regenerative medicine applications. This review will begin with an overview of the biological context of HA, which is needed to better understand how to engineer cell-matrix interactions in the scaffolds via the incorporation of different types of signals in order to direct and control cell behavior. Specifically, recent methods of incorporating various bioactive, mechanical and spatial signals are reviewed, as well as novel HA modifications and crosslinking schemes with a focus on specificity.
摘要
设计基于透明质酸（HA）的水凝胶支架以引发高度可控和可调的细胞反应及行为，是组织工程和再生医学应用开发中一个主要的研究领域。本综述将首先概述HA的生物学背景，这对于更好地理解如何通过在支架中引入不同类型的信号来构建细胞-基质相互作用，从而指导和控制细胞行为是必要的。具体而言，本文将综述近期整合各种生物活性、力学和空间信号的方法，以及重点关注特异性的新型HA修饰和交联方案。
相似文献
1
Design of cell-matrix interactions in hyaluronic acid hydrogel scaffolds.透明质酸水凝胶支架中细胞-基质相互作用的设计
Acta Biomater. 2014 Apr;10(4):1571-1580. doi: 10.1016/j.actbio.2013.07.025. Epub 2013 Jul 27.
2
Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering.用于人类神经干细胞和血管组织工程的鲑鱼纤维蛋白、透明质酸和层粘连蛋白组合支架
Acta Biomater. 2016 Oct 1;43:122-138. doi: 10.1016/j.actbio.2016.07.043. Epub 2016 Jul 27.
3
Hybrid hyaluronic acid hydrogel/poly(ɛ-caprolactone) scaffold provides mechanically favorable platform for cartilage tissue engineering studies.混合透明质酸水凝胶/聚己内酯支架为软骨组织工程研究提供了力学性能良好的平台。
J Biomed Mater Res A. 2014 Sep;102(9):2918-26. doi: 10.1002/jbm.a.34957. Epub 2013 Sep 30.
4
Characterization of glycidyl methacrylate - crosslinked hyaluronan hydrogel scaffolds incorporating elastogenic hyaluronan oligomers. characterization of glycidyl methacrylate - crosslinked hyaluronan hydrogel scaffolds incorporating elastogenic hyaluronan oligomers
Acta Biomater. 2011 Feb;7(2):653-65. doi: 10.1016/j.actbio.2010.08.006. Epub 2010 Aug 13.
5
Fabrication of single and bundled filament-like tissues using biodegradable hyaluronic acid-based hollow hydrogel fibers.使用可生物降解的基于透明质酸的中空水凝胶纤维制造单根和束状纤维状组织。
Int J Biol Macromol. 2017 Nov;104(Pt A):204-212. doi: 10.1016/j.ijbiomac.2017.06.013. Epub 2017 Jun 6.
6
Biocompatibility of hydrogel-based scaffolds for tissue engineering applications.水凝胶基支架的生物相容性在组织工程应用中的研究。
Biotechnol Adv. 2017 Sep;35(5):530-544. doi: 10.1016/j.biotechadv.2017.05.006. Epub 2017 May 27.
7
The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy.透明质酸水凝胶交联密度和高分子扩散率对人 MSC 软骨形成和肥大的影响。
Biomaterials. 2013 Jan;34(2):413-21. doi: 10.1016/j.biomaterials.2012.09.052. Epub 2012 Oct 22.
8
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review.基于透明质酸的水凝胶支架在角膜缘干细胞移植中的研究进展
Cells. 2019 Mar 14;8(3):245. doi: 10.3390/cells8030245.
9
The self-crosslinking smart hyaluronic acid hydrogels as injectable three-dimensional scaffolds for cells culture.自交联智能透明质酸水凝胶作为用于细胞培养的可注射三维支架。
Colloids Surf B Biointerfaces. 2016 Apr 1;140:392-402. doi: 10.1016/j.colsurfb.2016.01.008. Epub 2016 Jan 6.
10
A novel cell encapsulatable cryogel (CECG) with macro-porous structures and high permeability: a three-dimensional cell culture scaffold for enhanced cell adhesion and proliferation.一种具有大孔结构和高通透性的新型细胞可包封水凝胶（CECG）：一种用于增强细胞黏附和增殖的三维细胞培养支架。
Biomed Mater. 2019 Jul 19;14(5):055006. doi: 10.1088/1748-605X/ab2efd.
引用本文的文献
1
Advances in hyaluronic acid hydrogel for meniscus repair.用于半月板修复的透明质酸水凝胶的研究进展。
Front Bioeng Biotechnol. 2025 Jul 21;13:1639034. doi: 10.3389/fbioe.2025.1639034. eCollection 2025.
2
Hyaluronic Acid Influences Amino Acid Metabolism via Differential L-Type Amino Acid Transporter 1 Expression in the U87-Malignant Glioma Cell Line.透明质酸通过U87恶性胶质瘤细胞系中L型氨基酸转运体1的差异表达影响氨基酸代谢。
Adv Nanobiomed Res. 2024 Dec;4(12). doi: 10.1002/anbr.202400107. Epub 2024 Sep 2.
3
Biomaterial-assisted organoid technology for disease modeling and drug screening.用于疾病建模和药物筛选的生物材料辅助类器官技术。
Mater Today Bio. 2024 Dec 31;30:101438. doi: 10.1016/j.mtbio.2024.101438. eCollection 2025 Feb.
4
enhancement of CD8+ T cell activity using functionalized hydrogel encapsulating tonsil-derived lymphatic endothelial cells.使用包裹扁桃体来源的淋巴管内皮细胞的功能化水凝胶增强CD8 + T细胞活性。
Theranostics. 2025 Jan 1;15(3):850-874. doi: 10.7150/thno.100079. eCollection 2025.
5
Development and characterization of a novel injectable thyroid extracellular matrix hydrogel for enhanced thyroid tissue engineering applications.一种用于增强甲状腺组织工程应用的新型可注射甲状腺细胞外基质水凝胶的研制与表征
Front Bioeng Biotechnol. 2024 Nov 27;12:1481295. doi: 10.3389/fbioe.2024.1481295. eCollection 2024.
6
Blends of Silk Waste Protein and Polysaccharides for Enhanced Wound Healing and Tissue Regeneration: Mechanisms, Applications, and Future Perspectives.用于促进伤口愈合和组织再生的丝素蛋白与多糖混合物：作用机制、应用及未来展望
ACS Omega. 2024 Oct 25;9(44):44101-44119. doi: 10.1021/acsomega.4c06518. eCollection 2024 Nov 5.
7
Biomimetic composite gelatin methacryloyl hydrogels for improving survival and osteogenesis of human adipose-derived stem cells in 3D microenvironment.用于在三维微环境中提高人脂肪来源干细胞存活率和成骨能力的仿生复合甲基丙烯酰化明胶水凝胶
Mater Today Bio. 2024 Oct 9;29:101293. doi: 10.1016/j.mtbio.2024.101293. eCollection 2024 Dec.
8
Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review.水凝胶在椎间盘修复中的应用进展：综述
Curr Pain Headache Rep. 2024 Dec;28(12):1333-1348. doi: 10.1007/s11916-024-01296-6. Epub 2024 Jul 10.
9
Advances and challenges in regenerative therapies for abdominal aortic aneurysm.腹主动脉瘤再生疗法的进展与挑战
Front Cardiovasc Med. 2024 Jun 4;11:1369785. doi: 10.3389/fcvm.2024.1369785. eCollection 2024.
10
Efficacy and Safety of Neauvia Intense in Correcting Moderate-to-Severe Nasolabial Folds: A Post-Market, Prospective, Open-Label, Single-Centre Study.Neauvia Intense用于改善中重度鼻唇沟的疗效与安全性：一项上市后、前瞻性、开放标签、单中心研究
Clin Cosmet Investig Dermatol. 2024 Jun 10;17:1351-1363. doi: 10.2147/CCID.S460973. eCollection 2024.
本文引用的文献
1
Nanoscale Adhesion Ligand Organization Regulates Osteoblast Proliferation and Differentiation.纳米级黏附配体组织调控成骨细胞增殖与分化。
Nano Lett. 2004 Jul 13;4(8):1501-1506. doi: 10.1021/nl0493592.
2
Dynamic cell patterning of photoresponsive hyaluronic acid hydrogels.动态细胞图案化的光响应透明质酸水凝胶。
J Biomed Mater Res A. 2014 Feb;102(2):381-91. doi: 10.1002/jbm.a.34712. Epub 2013 May 14.
3
Oxime cross-linked injectable hydrogels for catheter delivery.用于导管递送的肟交联可注射水凝胶。
Adv Mater. 2013 Jun 4;25(21):2937-42. doi: 10.1002/adma.201205234. Epub 2013 Mar 12.
4
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.纤维蛋白（原）的肝素结合域与生长因子结合，并在合成基质中促进组织修复。
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4563-8. doi: 10.1073/pnas.1221602110. Epub 2013 Mar 4.
5
The modulation of MSC integrin expression by RGD presentation.通过整联蛋白表达的调制来实现间充质干细胞的黏附。
Biomaterials. 2013 May;34(16):3938-3947. doi: 10.1016/j.biomaterials.2013.01.091. Epub 2013 Mar 5.
6
Hyaluronic acid based scaffolds for tissue engineering--a review.基于透明质酸的组织工程支架——综述。
Carbohydr Polym. 2013 Feb 15;92(2):1262-79. doi: 10.1016/j.carbpol.2012.10.028. Epub 2012 Oct 17.
7
Hyaluronic acid click hydrogels emulate the extracellular matrix.透明质酸点击水凝胶模拟细胞外基质。
Langmuir. 2013 Jun 18;29(24):7393-400. doi: 10.1021/la305000w. Epub 2013 Feb 18.
8
Improving the osteogenic potential of BMP-2 with hyaluronic acid hydrogel modified with integrin-specific fibronectin fragment.用整合素特异性纤维连接蛋白片段修饰的透明质酸水凝胶提高 BMP-2 的成骨潜能。
Biomaterials. 2013 Jan;34(3):704-12. doi: 10.1016/j.biomaterials.2012.10.015. Epub 2012 Oct 24.
9
Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions.物理和化学微环境线索正交控制纤维化相关上皮间质转化的程度和持续时间。
J Pathol. 2013 Jan;229(1):25-35. doi: 10.1002/path.4114.
10
Biocompatible hydrogels by oxime Click chemistry.通过肟点击化学制备生物相容水凝胶。
Biomacromolecules. 2012 Oct 8;13(10):3013-7. doi: 10.1021/bm301346e. Epub 2012 Sep 12.
Zotero 插件