Axelsson Clas-Göran, Hallbäck Dan-Axel
Örebro University Hospital, Dept Transfusion Medicine, SE 701 85 Örebro, Sweden.
Transfus Apher Sci. 2013 Dec;49(3):652-4. doi: 10.1016/j.transci.2013.07.002. Epub 2013 Jul 27.
To demonstrate the efficacy of plasma exchange in primary biliary cirrhosis resistant to pharmacological treatment of pruritus.
Review of medical records and scientific literature of plasma exchange and pruritus in primary biliary cirrhosis.
Plasma exchange 2-3 times a month maintained pruritus at a subjectively acceptable level and at the same time preserved satisfactory liver function. In total more than 1000 plasma exchanges were given over these 26 years.
During these years the patient has been able to continue employment in spite of time consuming regular visits to an apheresis unit. She is now retired. The alternative was a liver transplant which was avoided. Although our patient is a unique case, plasma exchange should be considered in severe pruritus resistant to pharmacological treatment.
证明血浆置换在对瘙痒进行药物治疗无效的原发性胆汁性肝硬化中的疗效。
回顾原发性胆汁性肝硬化中血浆置换和瘙痒的病历及科学文献。
每月进行2 - 3次血浆置换可将瘙痒维持在患者主观可接受的水平，同时保持令人满意的肝功能。在这26年中总共进行了1000多次血浆置换。
在这些年里，尽管患者需要定期前往单采血浆站进行耗时的治疗，但仍能够继续工作。她现在已退休。原本的替代方案是肝移植，但避免了这种情况。虽然我们的患者是个独特案例，但对于对药物治疗无效的严重瘙痒，应考虑采用血浆置换。
