Lian Jing-cai, Zhang Shi-sheng, Zhang Jing, Ye Sheng
Department of New Vision Ophthalmology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025, China.
Zhonghua Yan Ke Za Zhi. 2013 Apr;49(4):305-8.
To determine flap thickness variation in 110 µm thickness flap made by FS200 femtosecond laser and sub-Bowman keratomileusis (SBK) microkeratome for studying the potential factors that affect the flap thickness.
It was a case-control study. Sixty patients were divided into two groups for laser in situ keratomileusis. The corneal flaps were made by using Alcon Wavelight FS200 femtosecond laser or MORIA SBK microkeratome. Central corneal flap thickness was calculated by subtraction pachymetry. Age, central corneal thickness (CCT), spherical equivalent refraction, mean keratometry and corneal diameter were recorded preoperatively for statistics.
This study comprised 120 eyes of 60 patients; 60 eyes were treated with each group. In Alcon Wavelight FS200 femtosecond laser group, the mean corneal flap thickness in the right and left eyes was (114.0 ± 6.6) and (111.4 ± 7.6) µm, respectively. The difference in corneal flap thickness between the right eye and the left eye (2.6 ± 9.1) µm was not statistically significant (t = 1.59, P = 0.12). Corneal flap thickness had no relationship with the age, preoperatively CCT, spherical equivalent refraction, corneal curvature and corneal diameter through stepwise regression analysis. In SBK microkeratome group, the mean corneal flap thickness in the right eye and the left eye was (110.6 ± 7.4) and (108.2 ± 6.1) µm respectively. The difference in corneal flap thickness between the right eye and the left eye (2.4 ± 6.6) µm was not statistically significant (t = 2.019, P = 0.054). Corneal flap thickness was positively correlated with preoperative CCT through stepwise regression analysis (r = 0.29, P = 0.021). Corneal flap thickness equaled to 67.77 + 0.076· CCT (F = 5.63, P = 0.021). Corneal flap thickness had no relationship with the age, spherical equivalent refraction, corneal curvature and corneal diameter.
Both FS200 femtosecond laser and SBK microkeratome can be used for making a good 110 µm thickness flap. Central corneal flap thickness was positively correlated with the preoperative CCT using the SBK microkeratome.
确定使用FS200飞秒激光制作的110μm厚度角膜瓣及准分子激光上皮瓣下角膜磨镶术（SBK）微型角膜刀制作的角膜瓣的厚度变化，以研究影响角膜瓣厚度的潜在因素。
这是一项病例对照研究。60例患者被分为两组接受准分子原位角膜磨镶术。角膜瓣分别使用爱尔康鹰视FS200飞秒激光或MORIA SBK微型角膜刀制作。通过减法测厚法计算中央角膜瓣厚度。术前记录年龄、中央角膜厚度（CCT）、等效球镜度、平均角膜曲率及角膜直径以进行统计学分析。
本研究纳入60例患者的120只眼；每组60只眼。在爱尔康鹰视FS200飞秒激光组，右眼和左眼的平均角膜瓣厚度分别为（114.0±6.6）μm和（111.4±7.6）μm。右眼和左眼之间角膜瓣厚度的差异（2.6±9.1）μm无统计学意义（t = 1.59，P = 0.12）。通过逐步回归分析，角膜瓣厚度与年龄、术前CCT、等效球镜度、角膜曲率及角膜直径均无关。在SBK微型角膜刀组，右眼和左眼的平均角膜瓣厚度分别为（110.6±7.4）μm和（108.2±6.1）μm。右眼和左眼之间角膜瓣厚度的差异（2.4±6.6）μm无统计学意义（t = 2.019，P = 0.054）。通过逐步回归分析，角膜瓣厚度与术前CCT呈正相关（r = 0.29，P = 0.021）。角膜瓣厚度等于67.77 + 0.076·CCT（F = 5.63，P = 0.021）。角膜瓣厚度与年龄、等效球镜度、角膜曲率及角膜直径均无关。
FS200飞秒激光和SBK微型角膜刀均可用于制作良好的110μm厚度角膜瓣。使用SBK微型角膜刀时，中央角膜瓣厚度与术前CCT呈正相关。
