Sneha Latha Magatha, Thanasegarapandian Kishore, Paramasivam Venkataraman, Scott Julius Xavier
Department of Pediatrics, Sri Ramachandra University, Chennai, Tamil Nadu, India.
Indian J Hum Genet. 2013 Jan;19(1):101-3. doi: 10.4103/0971-6866.112919.
Untreated hypothyroidism in children usually results in delayed puberty, but juvenile hypothyroidism causes isosexual precocious puberty in a rare syndrome called Van Wyk Grumbach syndrome, with a complete reversal to the pre pubertal state following thyroid hormone replacement therapy. We report here, a 7-year-old girl who presented with short stature, constipation and isosexual precocious puberty due to the long standing untreated severe hypothyroidism with this syndrome.
儿童未经治疗的甲状腺功能减退通常会导致青春期延迟，但青少年甲状腺功能减退在一种罕见的综合征——范怀克-格伦巴赫综合征中会导致同性性早熟，甲状腺激素替代治疗后会完全恢复到青春期前状态。我们在此报告一名7岁女孩，她因长期未经治疗的严重甲状腺功能减退伴该综合征而出现身材矮小、便秘和同性性早熟。
