Evers J L, Rolland R
Br J Obstet Gynaecol. 1981 Feb;88(2):195-202. doi: 10.1111/j.1471-0528.1981.tb00967.x.
A 14-year-old girl presented with precocious sexual development, galactorrhoea and symptoms and signs suggestive of hypothyroidism. On physical examination a tumour was found in the lower abdomen. Serum gonadotrophins, especially luteinizing hormone, serum thyroid stimulating hormone and prolactin were elevated. Measurement of thyroid hormones and additional thyroid function tests confirmed the diagnosis of primary hypothyroidism. Ultrasound investigation revealed the mass in the lower abdomen to be of a cystic nature and to originate from the right ovary. Following the institution of thyroid substitution therapy, all symptoms disappeared, biochemical and hormonal abnormalities returned to normal and the ovarian size decreased to normal. A hypothesis is presented for non-specific pituitary glycoprotein hormone synthesis secondary to the hypothyroidism, as the cause of the syndrome.
一名14岁女孩出现性早熟、溢乳以及提示甲状腺功能减退的症状和体征。体格检查发现下腹部有一个肿瘤。血清促性腺激素，尤其是黄体生成素、血清促甲状腺激素和催乳素升高。甲状腺激素测定及其他甲状腺功能检查确诊为原发性甲状腺功能减退。超声检查显示下腹部肿块为囊性，起源于右侧卵巢。甲状腺替代治疗开始后，所有症状消失，生化和激素异常恢复正常，卵巢大小恢复正常。本文提出一种假说，认为甲状腺功能减退继发的非特异性垂体糖蛋白激素合成是该综合征的病因。
