Nanoprobes, Yaphank, NY, USA.
Int J Nanomedicine. 2013;8:2521-32. doi: 10.2147/IJN.S43770. Epub 2013 Jul 17.
Magnetic nanoparticles heated by an alternating magnetic field could be used to treat cancers, either alone or in combination with radiotherapy or chemotherapy. However, direct intratumoral injections suffer from tumor incongruence and invasiveness, typically leaving undertreated regions, which lead to cancer regrowth. Intravenous injection more faithfully loads tumors, but, so far, it has been difficult achieving the necessary concentration in tumors before systemic toxicity occurs. Here, we describe use of a magnetic nanoparticle that, with a well-tolerated intravenous dose, achieved a tumor concentration of 1.9 mg Fe/g tumor in a subcutaneous squamous cell carcinoma mouse model, with a tumor to non-tumor ratio > 16. With an applied field of 38 kA/m at 980 kHz, tumors could be heated to 60°C in 2 minutes, durably ablating them with millimeter (mm) precision, leaving surrounding tissue intact.
交变磁场加热的磁性纳米粒子可单独或与放射疗法或化学疗法联合用于治疗癌症。然而，直接瘤内注射存在肿瘤不一致和侵袭性问题，通常会留下治疗不充分的区域，导致癌症复发。静脉内注射更能准确地加载肿瘤，但到目前为止，在发生全身毒性之前，很难在肿瘤中达到必要的浓度。在这里，我们描述了一种磁性纳米粒子的使用方法，该纳米粒子以可耐受的静脉剂量，在皮下鳞状细胞癌小鼠模型中实现了 1.9mgFe/g 肿瘤的浓度，肿瘤与非肿瘤的比值>16。在 980kHz 时施加 38kA/m 的磁场，肿瘤可在 2 分钟内加热至 60°C，可精确地进行毫米（mm）级的持久消融，而周围组织保持完整。
