金纳米颗粒成像与小鼠脑肿瘤放疗。
Gold nanoparticle imaging and radiotherapy of brain tumors in mice.
机构信息
Nanoprobes, Inc., 95 Horseblock Road, Unit 1 Yaphank, NY 11980, USA.
出版信息
Nanomedicine (Lond). 2013 Oct;8(10):1601-9. doi: 10.2217/nnm.12.165. Epub 2012 Dec 24.
Abstract
AIM
To test intravenously injected gold nanoparticles for x-ray imaging and radiotherapy enhancement of large, imminently lethal, intracerebral malignant gliomas.
MATERIALS & METHODS: Gold nanoparticles approximately 11 nm in size were injected intravenously and brains imaged using microcomputed tomography. A total of 15 h after an intravenous dose of 4 g Au/kg was administered, brains were irradiated with 30 Gy 100 kVp x-rays.
RESULTS
Gold uptake gave a 19:1 tumor to normal brain ratio with 1.5% w/w gold in tumor, calculated to increase local radiation dose by approximately 300%. Mice receiving gold and radiation (30 Gy) demonstrated 50% long term (>1 year) tumor-free survival, whereas all mice receiving radiation only died.
CONCLUSION
Intravenously injected gold nanoparticles cross the blood-tumor barrier, but are largely blocked by the normal blood-brain barrier, enabling high-resolution computed tomography tumor imaging. Gold radiation enhancement significantly improved long-term survival compared with radiotherapy alone. This approach holds promise to improve therapy of human brain tumors and other cancers.
摘要
目的
测试静脉注射金纳米粒子在 X 射线成像和放射治疗方面对大型、致命性脑内恶性胶质瘤的增强作用。
材料与方法
静脉注射大小约为 11nm 的金纳米粒子，并用微计算机断层扫描进行脑部成像。在静脉注射 4gAu/kg 的金纳米粒子 15 小时后，用 30Gy100kVpX 射线进行脑部照射。
结果
金的摄取使肿瘤与正常脑组织的比值达到 19:1，肿瘤中含有 1.5%的金，计算得出局部放射剂量增加了约 300%。接受金和放射治疗（30Gy）的小鼠有 50%（>1 年）的肿瘤无长期生存，而仅接受放射治疗的小鼠全部死亡。
结论
静脉注射的金纳米粒子可以穿过血脑肿瘤屏障，但大部分被正常的血脑屏障所阻断，从而能够进行高分辨率计算机断层扫描肿瘤成像。金的放射增强作用与单纯放射治疗相比，显著提高了长期生存率。这种方法有望改善人类脑肿瘤和其他癌症的治疗效果。
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