Wilkins Patricia P, Qvarnstrom Yvonne, Whelen A Christian, Saucier Caitlin, da Silva Alexandre J, Eamsobhana Praphathip
Division of Parasitic Diseases & Malaria, Centers for Disease Control & Prevention, Atlanta, GA 30329 , USA.
Hawaii J Med Public Health. 2013 Jun;72(6 Suppl 2):55-7.
Laboratory diagnosis of angiostrongyliasis relies on serological techniques, since definitive diagnosis is insensitive. Modern antibody detection methods focus on antibodies to the 29 and 31 kDa proteins of the parasite. Antigen detection may ultimately prove to be more reliable than antibody detection but no method has been adopted for clinical diagnostic use. Diagnosis using PCR amplification of DNA sequences specific to Angiostrongylus cantonensis have been developed but have not yet been validated for clinical use. Diagnostic tests have not been developed commercially and in the United States tests developed experimentally by non-commercial laboratories have to be approved by the Food and Drug Administration before they can be sold to other laboratories for diagnostic purposes.
广州管圆线虫病的实验室诊断依赖血清学技术，因为确诊诊断并不敏感。现代抗体检测方法聚焦于针对该寄生虫29 kDa和31 kDa蛋白的抗体。抗原检测最终可能被证明比抗体检测更可靠，但尚无方法被用于临床诊断。利用聚合酶链反应（PCR）扩增广州管圆线虫特异性DNA序列的诊断方法已被开发出来，但尚未得到临床应用验证。诊断检测尚未商业化开发，在美国，由非商业实验室实验性开发的检测必须得到食品药品监督管理局的批准才能出售给其他实验室用于诊断目的。
