[枸骨根的化学成分]

[Chemical constituents from the root of Ilex cornuta].

作者信息

Zhou Xi-Xi, Xu Qiong-Ming, Zhou Ying, Li Xiao-Ran, Yang Shi-Lin

机构信息

College of Life Sciences, Guizhou University, Guiyang 550025, China.

出版信息

Zhong Yao Cai. 2013 Feb;36(2):233-6.

PMID:23901650

Abstract

OBJECTIVE

To investigate the chemical constituents of the root of Ilex cornuta.

METHODS

The constituents were isolated by silica gel, Sephadex LH-20 gel, medium pressure column and semi-preparative liquid chromatography and their structures were elucidated by chemical properties and spectroscopic analyses.

RESULTS

Ten compounds were isolated and their structures were identified as: Oleanolic acid (1), Siaresinolic acid (2), 28-O-beta-D-glucopyranosyl pomolic acid (3), Pomolic acid (4), 3beta-O-alpha-L-arabinopyranosyl rotundic acid (5), 3beta-[alpha-L-arabinopyranosyl) oxy]-19alpha-hydroxyolean-12-en-28-oic acid 28-beta-D-glucopyranosyl ester (6), Lup-20(29)-en-3beta,23-diol (7), Chikusetsusaponin IV a butyl ester (8), Oleanolic acid-3-O-( 6'-O-methyl)-beta-D-glucuronopyranoside (9), 3-O-[(alpha-L-arabinopyranosyl)-(1 --> 2)]-beta-D-glucuronopyranosyl-(6'-O-methyl-ester)-olean-12-ene-28-olic acid (10).

CONCLUSION

Compounds 7 - 10 are isolated from this genus for the first time, and compounds 2 - 6 are isolated from this plant for the first time.

摘要

目的

研究枸骨根的化学成分。

方法

采用硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱、中压柱色谱及半制备液相色谱法分离化合物，并通过化学性质和光谱分析确定其结构。

结果

分离得到10个化合物，其结构分别鉴定为：齐墩果酸（1）、蛇麻脂醇酸（2）、28 - O - β - D - 吡喃葡萄糖基坡模酸（3）、坡模酸（4）、3β - O - α - L - 吡喃阿拉伯糖基圆椎酸（5）、3β - [α - L - 吡喃阿拉伯糖基）氧基] - 19α - 羟基齐墩果 - 12 - 烯 - 28 - 酸28 - β - D - 吡喃葡萄糖基酯（6）、羽扇 - 20（29） - 烯 - 3β，23 - 二醇（7）、竹节人参皂苷IV a丁酯（8）、齐墩果酸 - 3 - O - （6'-O - 甲基） - β - D - 葡萄糖醛酸吡喃糖苷（9）、3 - O - [（α - L - 吡喃阿拉伯糖基） - （1→2）] - β - D - 葡萄糖醛酸吡喃糖基 - （6'-O - 甲基酯） - 齐墩果 - 12 - 烯 - 28 - 醇酸（10）。