Department of Surgery, University of Medicine & Dentistry, New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Future Oncol. 2013 Aug;9(8):1121-32. doi: 10.2217/fon.13.66.
Patients with glioblastoma typically present when tumors are at an advanced stage. Surgical resection, radiotherapy and adjuvant chemotherapy are currently the standard of care for glioblastoma. However, due to the infiltrative and dispersive nature of the tumor, recurrence rate remains high and typically results in very poor prognosis. Efforts to treat the primary tumor are, therefore, palliative rather than curative. From a practical perspective, controlling growth and dispersal of the recurrence may have a greater impact on disease-free survival. In order for cells to disperse, they must first detach from the mass. Preventing detachment may keep tumors that recur more localized and perhaps more amenable to therapy. Here we introduce a new perspective in which a quantifiable mechanical property, namely tissue surface tension, can provide novel information on tumor behavior. The overall theme of the discussion will attempt to integrate how adhesion molecules can alter a tumor's mechanical properties and how, in turn, these properties can be modified to prevent tumor cell detachment and dispersal.
胶质母细胞瘤患者通常在肿瘤处于晚期时出现。目前，手术切除、放疗和辅助化疗是胶质母细胞瘤的标准治疗方法。然而，由于肿瘤的浸润和弥散特性，复发率仍然很高，通常导致预后非常差。因此，治疗原发性肿瘤主要是姑息性的，而不是治愈性的。从实际的角度来看，控制复发的生长和扩散可能对无病生存期有更大的影响。为了使细胞扩散，它们必须首先从肿瘤上脱离。防止脱离可能会使复发的肿瘤更加局限，也许更容易进行治疗。在这里，我们引入了一个新的视角，即一种可量化的力学特性，即组织表面张力，可以为肿瘤行为提供新的信息。讨论的总体主题将试图整合粘附分子如何改变肿瘤的力学特性，以及这些特性如何被改变以防止肿瘤细胞脱离和扩散。
