Institute for Experimental Pathology, University of Iceland, Keldur, 112 Reykjavik, Iceland.
Viruses. 2013 Jul 30;5(8):1934-47. doi: 10.3390/v5081934.
It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.
越来越明显的是，生物已经发展出多种机制来对抗病毒感染。病毒也以各种方式发展出了对抗这些防御的手段。APOBEC3 蛋白是哺乳动物特有的一类核酸胞嘧啶脱氨酶，可阻止逆转录病毒感染。大多数慢病毒编码的 Vif 蛋白可中和这些抑制剂。在本文中，我们将回顾慢病毒 Vif 蛋白与 APOBEC3 蛋白的相互作用，重点介绍绵羊 APOBEC3 和绵羊肺腺瘤病毒（MVV）Vif。
