Departments of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N. Greene Street, Baltimore, Maryland, 21201, USA.
AAPS J. 2013 Oct;15(4):1064-71. doi: 10.1208/s12248-013-9513-3. Epub 2013 Aug 1.
Epigenetics is an important emerging area for study of mechanisms of cancer prevention. In recent years, it has been realized that cancer prevention agents, derived from natural dietary sources, impact cancer cell survival by modulating epigenetic processes. In the present manuscript, we review key epigenetic regulatory mechanisms and examine the impact of sulforaphane and green tea polyphenols on these processes. We also discuss available information on the epigenetics in the context of skin cancer. These studies indicate that diet-derived chemopreventive agents modulate DNA methylation status and histone modification via multiple processes and point to additional areas for study of epigenetic mechanisms in skin cancer.
表观遗传学是癌症预防机制研究的一个重要新兴领域。近年来，人们已经意识到，源自天然饮食来源的癌症预防剂通过调节表观遗传过程来影响癌细胞的存活。在本手稿中，我们回顾了关键的表观遗传调控机制，并研究了萝卜硫素和绿茶多酚对这些过程的影响。我们还讨论了有关皮肤癌表观遗传学的现有信息。这些研究表明，饮食来源的化学预防剂通过多种途径调节 DNA 甲基化状态和组蛋白修饰，并指出了皮肤癌中表观遗传机制研究的其他领域。
