三萜类化合物在癌症预防和健康方面的表观遗传学/表观基因组学。
Epigenetics/epigenomics of triterpenoids in cancer prevention and in health.
机构信息
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
出版信息
Biochem Pharmacol. 2020 May;175:113890. doi: 10.1016/j.bcp.2020.113890. Epub 2020 Feb 29.
Triterpenoids are a powerful group of phytochemicals derived from plant foods and herbs. Many reports have shown that they possess chemopreventive and chemotherapeutic effects not only in cell lines and animal models but also in clinical trials. Because epigenetic changes could potentially occur in the early stages of carcinogenesis preceding genetic mutations, epigenetics are considered promising targets in early interventions against cancer using epigenetic bioactive substances. The biological properties of triterpenoids in cancer prevention and in health have multiple mechanisms, including antioxidant and anti-inflammatory activities, cell cycle regulation, as well as epigenetic/epigenomic regulation. In this review, we will discuss and summarize the latest advances in the study of the pharmacological effects of triterpenoids in cancer chemoprevention and in health, including the epigenetic machinery.
三萜类化合物是一类源自植物性食物和草药的强效植物化学物质。许多报告表明，它们不仅在细胞系和动物模型中，而且在临床试验中都具有化学预防和化学治疗作用。由于表观遗传变化可能在遗传突变之前的癌症发生早期发生，因此表观遗传学被认为是使用表观遗传生物活性物质进行癌症早期干预的有前途的靶点。三萜类化合物在癌症预防和健康方面的生物学特性具有多种机制，包括抗氧化和抗炎活性、细胞周期调节以及表观遗传/表观基因组调节。在这篇综述中，我们将讨论和总结三萜类化合物在癌症化学预防和健康中的药理学作用的最新研究进展，包括表观遗传机制。
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