Wang Hua, Wang Wenjian, Yang Dongjie, Wang Shenming
Division of Vascular, Thyroid and Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.
Tumour Biol. 2014 Jan;35(1):93-102. doi: 10.1007/s13277-013-1011-9. Epub 2013 Aug 1.
Previous studies on the association of Vitamin D receptor (VDR) TaqI gene polymorphism with breast carcinogenesis have yielded inconsistent and inconclusive findings. The current meta-analysis was performed to provide a more precise assessment on the role of VDR TaqI polymorphism in breast cancer risk. 20 eligible case-control studies involving 9,055 cases and 10,516 controls were identified after a comprehensive literature search of the PubMed, Embase, Web of Science, and Wanfang databases. The pooled odds ratio (OR) with corresponding 95% confidence interval (95% CI) was calculated. Stratified analyses by ethnicity and study quality were conducted for further estimation. All statistical analyses were conducted by use of STATA (STATA Corporation, College Station, TX, Version 11.0). The overall ORs showed that the variant t allele and tt genotype were related to an increased risk of breast cancer (OR(t vs. T) = 1.05, 95% CI 1.01-1.10, P(OR) = 0.025; OR(tt vs. TT) = 1.12, 95% CI 1.03-1.23, P(OR) = 0.011; OR(tt vs. Tt + TT) = 1.10, 95% CI 1.01-1.20, P(OR) = 0.023). Stratified analyses of studies in Caucasians and with high-quality further confirmed the results. However, no significant relationship was observed among Asians. This meta-analysis suggests that the VDR TaqI polymorphism confers risk effect on the breast cancer development, particularly in Caucasians.
先前关于维生素D受体（VDR）TaqI基因多态性与乳腺癌发生之间关联的研究结果并不一致且尚无定论。进行当前的荟萃分析是为了更精确地评估VDR TaqI基因多态性在乳腺癌风险中的作用。在对PubMed、Embase、Web of Science和万方数据库进行全面文献检索后，确定了20项符合条件的病例对照研究，涉及9055例病例和10516例对照。计算了合并优势比（OR）及相应的95%置信区间（95%CI）。通过种族和研究质量进行分层分析以作进一步评估。所有统计分析均使用STATA（STATA公司，德克萨斯州大学城，版本11.0）进行。总体OR显示，变异的t等位基因和tt基因型与乳腺癌风险增加相关（OR（t对T）=1.05，95%CI 1.01 - 1.10，P（OR）=0.025；OR（tt对TT）=1.12，95%CI 1.03 - 1.23，P（OR）=0.011；OR（tt对Tt + TT）=1.10，95%CI 1.01 - 1.20，P（OR）=0.023）。对高加索人群研究和高质量研究的分层分析进一步证实了这些结果。然而，在亚洲人群中未观察到显著关联。这项荟萃分析表明，VDR TaqI基因多态性对乳腺癌发展具有风险效应，尤其是在高加索人群中。
