College of Stomatology, Chongqing Medical University, Chongqing, China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, China.
Genet Test Mol Biomarkers. 2021 May;25(5):368-375. doi: 10.1089/gtmb.2020.0263. Epub 2021 May 6.
This study investigated the association of the I (rs731236 T>C) polymorphism in the gene with dental caries. A comprehensive literature search was performed in PubMed, Web of Science, Embase, SinoMed (the Chinese biomedical literature service system), and the Wiley Online Library. Overall comparisons and subgroup analyses based on ethnicity and the presence of dental caries in dentition were performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess associations between gene polymorphisms and the risk of dental caries. Seven articles were included in this meta-analysis. The pooled results revealed a significant association of the I (rs731236 T>C) polymorphism with dental caries in the allele contrast model (C vs. T: OR = 1.24, 95% CI = 1.07-1.44, = 42%, = 0.005) and in the recessive genetic model (CC vs. TT/CT: OR = 1.38, 95% CI = 1.03-1.84, = 0%, = 0.03). A stratified analysis based on ethnicity revealed a significant association between the I (rs731236 T>C) polymorphism and the risk of dental caries in Asians (C vs. T: OR = 1.28, 95% CI = 1.06-1.54, = 60%, = 0.009). Subgroup analysis based on the presence of dental caries in dentition found a significant association of the I (rs731236 T>C) polymorphism with permanent tooth caries in the allele contrast model (C vs. T: OR = 1.40, 95% CI = 1.11-1.77, = 76%, = 0.005) and the recessive genetic model (CC vs. TT/CT: OR = 1.44, 95% CI = 1.03-2.00, = 0%, = 0.03). The results of this meta-analysis suggest that the C allele and CC genotype of the I (rs731236 T>C) polymorphism in the gene are associated with an increased risk of dental caries.
本研究探讨了基因中的 I(rs731236 T>C) 多态性与龋齿的关系。我们在 PubMed、Web of Science、Embase、SinoMed（中国生物医学文献服务系统）和 Wiley Online Library 中进行了全面的文献检索。根据种族和牙齿中龋齿的存在情况，进行了总体比较和亚组分析。使用优势比（OR）及其 95%置信区间（CI）来评估基因多态性与龋齿风险之间的关联。这项荟萃分析纳入了 7 篇文章。汇总结果显示，在等位基因对比模型（C 对 T：OR=1.24，95%CI=1.07-1.44，=42%，=0.005）和隐性遗传模型（CC 对 TT/CT：OR=1.38，95%CI=1.03-1.84，=0%，=0.03）中，I(rs731236 T>C) 多态性与龋齿显著相关。基于种族的分层分析显示，I(rs731236 T>C) 多态性与亚洲人群龋齿风险之间存在显著关联（C 对 T：OR=1.28，95%CI=1.06-1.54，=60%，=0.009）。基于牙齿中龋齿存在情况的亚组分析发现，在等位基因对比模型（C 对 T：OR=1.40，95%CI=1.11-1.77，=76%，=0.005）和隐性遗传模型（CC 对 TT/CT：OR=1.44，95%CI=1.03-2.00，=0%，=0.03）中，I(rs731236 T>C) 多态性与恒牙龋齿显著相关。这项荟萃分析的结果表明，基因中的 I(rs731236 T>C) 多态性的 C 等位基因和 CC 基因型与龋齿风险增加相关。
