5-羟色胺3受体拮抗剂ICS 205-930对脂肪延缓胃排空及胃窦运动活性的影响。
Effects of the 5-HT3 receptor antagonist ICS 205-930 on fat-delayed gastric emptying and antral motor activity.
作者信息
Stacher G, Bergmann H, Schneider C, Steiner-Mittelbach G, Gaupmann G, Steinringer H, Abatzi T A, Stacher-Janotta G
机构信息
Department of Psychiatry, University of Vienna, Austria.
出版信息
Br J Clin Pharmacol. 1990 Jul;30(1):41-8. doi: 10.1111/j.1365-2125.1990.tb03741.x.
Abstract
- The selective 5-HT3 receptor antagonist, ICS 205-930 (Sandoz), has been reported to have potent effects on gastric smooth muscle in vivo and to enhance gastric emptying in animals and in man. 2. This study investigated the effects of ICS 205-930 on fat-delayed gastric emptying of a semisolid meal and antral motor activity in humans. 3. Twelve healthy men participated in each of three studies in which 10 or 20 mg of ICS 205-930 or placebo were infused i.v. in a random double-blind fashion. Gastric emptying and antral motor activity were studied scintigraphically. 4. Gastric emptying was not altered after 10 mg but slower after 20 mg of ICS 205-930 than after placebo. Emptying after 20 mg of ICS 205-930 was significantly slower than after 10 mg of ICS 205-930. 5. Antral contraction amplitude was slightly lower after 20 mg of ICS 205-930 than after placebo, whereas the effects of 10 mg ICS 205-930 did not differ from those of placebo. 6. The results suggest that the investigated doses of ICS 205-930 have only slight effects on gastric motor activity of healthy young men, with 20 mg reducing the rate of emptying.
摘要
- 据报道，选择性5-羟色胺3（5-HT3）受体拮抗剂ICS 205-930（山德士公司）对体内胃平滑肌有显著作用，可促进动物和人体的胃排空。2. 本研究调查了ICS 205-930对人体半固体餐脂肪延迟胃排空及胃窦运动活性的影响。3. 12名健康男性参与了三项研究，每项研究中，10毫克或20毫克的ICS 205-930或安慰剂以随机双盲方式静脉输注。通过闪烁扫描法研究胃排空和胃窦运动活性。4. 10毫克ICS 205-930后胃排空未改变，但20毫克ICS 205-930后胃排空比安慰剂后更慢。20毫克ICS 205-930后的排空明显慢于10毫克ICS 205-930后的排空。5. 20毫克ICS 205-930后胃窦收缩幅度略低于安慰剂后，而10毫克ICS 205-930的效果与安慰剂无差异。6. 结果表明，所研究剂量的ICS 205-930对健康年轻男性的胃运动活性仅有轻微影响，20毫克可降低排空速率。
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本文引用的文献
1
The pattern of emptying of the human stomach.人类胃部的排空模式。
J Physiol. 1951 Apr;113(2-3):157-68. doi: 10.1113/jphysiol.1951.sp004562.
2
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Gut. 1984 May;25(5):485-90. doi: 10.1136/gut.25.5.485.
3
Inhibition of gastric emptying in humans by secretion, the octapeptide of cholecystokinin, and intraduodenal fat.胆囊收缩素八肽分泌、十二指肠内脂肪对人体胃排空的抑制作用。
Gastroenterology. 1981 Nov;81(5):898-902.
4
A relation between gastroduodenal muscle contractions and gastric empyting.胃十二指肠肌肉收缩与胃排空之间的关系。
Gut. 1969 Jul;10(7):543-8. doi: 10.1136/gut.10.7.543.
5
Relation between antral motility and gastric emptying of solids and liquids in humans.人体胃窦运动与固体和液体胃排空之间的关系。
Am J Physiol. 1985 Nov;249(5 Pt 1):G580-5. doi: 10.1152/ajpgi.1985.249.5.G580.
6
Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs.5-羟色胺M受体亚型的鉴定及其被一类新型药物的特异性阻断
Nature. 1985;316(6024):126-31. doi: 10.1038/316126a0.
7
5-Hydroxytryptamine M-receptor antagonism to prevent cisplatin-induced emesis.5-羟色胺M受体拮抗作用预防顺铂所致呕吐。
Neuropharmacology. 1986 Aug;25(8):959-61. doi: 10.1016/0028-3908(86)90030-4.
8
Intravenous cisapride accelerates delayed gastric emptying and increases antral contraction amplitude in patients with primary anorexia nervosa.静脉注射西沙必利可加速原发性神经性厌食症患者延迟的胃排空，并增加胃窦收缩幅度。
Gastroenterology. 1987 Apr;92(4):1000-6. doi: 10.1016/0016-5085(87)90976-0.
9
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Remission of symptoms in carcinoid syndrome with a new 5-hydroxytryptamine M receptor antagonist.新型5-羟色胺M受体拮抗剂治疗类癌综合征的症状缓解情况
Br Med J (Clin Res Ed). 1987 May 2;294(6580):1129. doi: 10.1136/bmj.294.6580.1129.
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