Huang Yi-Ming, Xia Wei, Ge Yi-Jun, Hou Jia-Hui, Tan Lan, Xu Wei, Tan Chen-Chen
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Department of Cardiology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Front Cardiovasc Med. 2022 Sep 27;9:907990. doi: 10.3389/fcvm.2022.907990. eCollection 2022.
The effect of extreme sleep duration on the risk of cardiovascular and cerebrovascular diseases (CCDs) remains debatable. The pathology of CCDs is consistent in some respects (e.g., vascular factors), suggesting that there may be an overlapping range of sleep duration associated with a low risk of both diseases We aimed to quantify the dose-response relationship between sleep duration and CCDs.
To explore whether there is an optimal sleep duration (SD) in reducing the risk of CCDs.
PubMed and EMBASE were searched until June 24, 2022 to include cohort studies that investigated the longitudinal relationships of SD with incident CCDs, including stroke and coronary heart disease (CHD). The robusterror meta-regression model (REMR model) was conducted to depict the dose-response relationships based on multivariate-adjusted risk estimates.
A total of 71 cohorts with 3.8 million participants were included for meta-analysis, including 57 for cardiovascular diseases (CVD) and 29 for cerebrovascular disease. A significant U-shaped relationship was revealed of nighttime sleep duration with either cardiovascular or cerebrovascular disease. The nighttime sleep duration associated with a lower risk of CVD was situated within 4.3-10.3 h, with the risk hitting bottom at roughly 7.5 h per night ( < 0.0001). Sleep duration associated with a lower risk of cerebrovascular diseases ranges from 5 to 9.7 h per night, with the inflection at 7.5 h per night ( = 0.05). Similar non-linear relationship exited in daily sleep duration and CCDs. Other subgroup analyses showed non-linear relationships close to the above results.
Rational sleep duration (7.5 h/night) is associated with a reduced risk of cardio-cerebrovascular disease for adults.
极端睡眠时间对心血管和脑血管疾病（CCDs）风险的影响仍存在争议。CCDs的病理在某些方面是一致的（例如血管因素），这表明可能存在一个与两种疾病低风险相关的重叠睡眠时间范围。我们旨在量化睡眠时间与CCDs之间的剂量反应关系。
探讨在降低CCDs风险方面是否存在最佳睡眠时间（SD）。
检索PubMed和EMBASE直至2022年6月24日，纳入调查SD与CCDs（包括中风和冠心病（CHD））发病纵向关系的队列研究。基于多变量调整后的风险估计，采用稳健误差元回归模型（REMR模型）来描述剂量反应关系。
共纳入71个队列，380万参与者进行荟萃分析，其中57个队列研究心血管疾病（CVD），29个队列研究脑血管疾病。夜间睡眠时间与心血管或脑血管疾病之间呈现出显著的U型关系。与较低CVD风险相关的夜间睡眠时间在4.3 - 10.3小时之间，风险在每晚约7.5小时时达到最低点（<0.0001）。与较低脑血管疾病风险相关的睡眠时间为每晚5至9.7小时，转折点为每晚7.5小时（=0.05）。每日睡眠时间与CCDs之间也存在类似的非线性关系。其他亚组分析显示出与上述结果相近的非线性关系。
合理的睡眠时间（每晚7.5小时）与成年人降低心脑血管疾病风险相关。
