Department of Psychiatry, University of California San Diego, San Diego, CA 92093-0733, USA.
Sleep. 2013 Aug 1;36(8):1209-17. doi: 10.5665/sleep.2888.
To assess the usefulness of actigraphy for assessment of nighttime sleep measures in patients with Parkinson's disease (PD).
Participants underwent overnight sleep assessment simultaneously by polysomnography (PSG) and actigraphy.
Overnight sleep study in academic sleep research laboratory.
Sixty-one patients (mean age 67.74 ± 8.88 y) with mild to moderate PD.
Sleep measures including total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), and sleep onset latency (SOL) were calculated independently from data derived from PSG and from actigraphy. Different actigraphy scoring settings were compared.
No single tested actigraphy scoring setting was optimal for all sleep measures. A customized setting of an activity threshold of 10, with five consecutive immobile minutes for sleep onset, yielded the combination of mean TST, SE, and WASO values that best approximated mean values determined by PSG with differences of 6.05 ± 85.67 min for TST, 1.1 ± 0.641% for SE, and 4.35 ± 59.56 min for WASO. There were significant but moderate correlations between actigraphy and PSG measurements (rs = 0.496, P < 0.001 for TST, rs = 0.384, P = 0.002 for SE, and rs = 0.400, P = 0.001 for WASO) using these settings. Greater disease stage was associated with greater differences between TST (R(2) = 0.099, beta = 0.315, P = 0.018), SE (R(2) = 0.107, beta = 0.327, P = 0.014), and WASO (R(2) = 0.094, beta = 0.307, P = 0.021) values derived by actigraphy and PSG explaining some of the variability. Using a setting of 10 immobile min for sleep onset yielded a mean SOL that was within 1 min of that estimated by PSG. However SOL values determined by actigraphy and PSG were not significantly correlated at any tested setting.
Our results suggest that actigraphy may be useful for measurement of mean TST, SE, and WASO values in groups of patients with mild to moderate Parkinson's disease. However, there is a significant degree of variability in accuracy among individual patients. The importance of determining optimal scoring parameters for each population studied is underscored.
评估活动记录仪在评估帕金森病（PD）患者夜间睡眠测量中的有用性。
参与者同时接受多导睡眠图（PSG）和活动记录仪的夜间睡眠评估。
学术睡眠研究实验室的夜间睡眠研究。
61 名患者（平均年龄 67.74±8.88 岁），轻度至中度 PD。
睡眠测量包括总睡眠时间（TST）、睡眠效率（SE）、睡眠后觉醒（WASO）和睡眠潜伏期（SOL），分别从 PSG 和活动记录仪数据中计算得出。比较了不同的活动记录仪评分设置。
没有一种单一的活动记录仪评分设置适用于所有睡眠测量。活动阈值为 10，睡眠起始时有连续 5 分钟的不活动，可获得 TST、SE 和 WASO 平均值的最佳组合，与 PSG 确定的平均值相差 6.05±85.67min、1.1±0.641%的 SE 和 4.35±59.56min。使用这些设置，活动记录仪和 PSG 测量之间存在显著但中度的相关性（r=0.496，P<0.001 用于 TST，r=0.384，P=0.002 用于 SE，r=0.400，P=0.001 用于 WASO）。疾病阶段越大，TST（R（2）=0.099，β=0.315，P=0.018）、SE（R（2）=0.107，β=0.327，P=0.014）和 WASO（R（2）=0.094，β=0.307，P=0.021）之间的差异越大，解释了一些可变性。使用睡眠起始时 10 分钟不活动的设置可获得与 PSG 估计值相差 1 分钟的平均 SOL。然而，在任何测试设置下，活动记录仪和 PSG 确定的 SOL 值均无显著相关性。
我们的结果表明，活动记录仪可用于测量轻度至中度帕金森病患者群体的平均 TST、SE 和 WASO 值。然而，个体患者的准确性存在显著差异。强调了为每个研究人群确定最佳评分参数的重要性。
