Neuroscience and Motor Control Group (NEUROcom), Department of Medicine-INEF and Institute for Biomedical Research (INIBIC), University of A Coruña, Spain.
Sleep Med. 2010 Sep;11(8):759-65. doi: 10.1016/j.sleep.2010.05.003. Epub 2010 Jul 31.
A recent report indicates repetitive transcranial magnetic stimulation (rTMS) improves sleep in Parkinson's disease (PD). The aim of this work is to evaluate the effect of 10days rTMS on sleep parameters in PD patients.
Double-blind, placebo-controlled design. Eighteen idiopathic PD patients completed the study. Sleep parameters were evaluated through actigraphy and the Parkinson's Disease Sleep Scale (PDSS), along with depression (Hamilton Depression Rating Scale, HDS), and the Unified Parkinson's Disease Rating Scale (UPDRS). Evaluations were carried out before treatment with rTMS (pre-evaluation, PRE), after the rTMS treatment programme (post-evaluation, POST), and one week after POST (POST-2). Nine PD patients received real rTMS and the other 9 received sham rTMS daily for 10days, (100 pulses at 1Hz) applied with a large circular coil over the vertex.
Stimulation had no effect over actigraphic variables. Conversely PDSS, HDS, and UPDRS were significantly improved by the stimulation. Notably, however, these changes were found equally in groups receiving real or sham stimulation.
rTMS, using our protocol, has no therapeutic value on the sleep of PD patients, when compared to appropriate sham controls. Future works assessing the possible therapeutic role of rTMS on sleep in PD should control the effect of placebo.
最近的一份报告表明，重复经颅磁刺激（rTMS）可改善帕金森病（PD）患者的睡眠。本研究旨在评估 10 天 rTMS 对 PD 患者睡眠参数的影响。
双盲、安慰剂对照设计。18 例特发性 PD 患者完成了这项研究。通过活动记录仪和帕金森病睡眠量表（PDSS）评估睡眠参数，同时评估抑郁（汉密尔顿抑郁评定量表，HDS）和帕金森病综合评分量表（UPDRS）。在 rTMS 治疗前（预评估，PRE）、rTMS 治疗后（后评估，POST）以及 POST 后一周（POST-2）进行评估。9 例 PD 患者接受真 rTMS 治疗，9 例接受假 rTMS 治疗，每天 10 次，（1Hz 时 100 个脉冲）在顶点处使用大圆形线圈进行刺激。
刺激对活动记录仪变量没有影响。相反，PDSS、HDS 和 UPDRS 均显著改善。然而，在接受真刺激或假刺激的两组中，均发现了这些变化。
与适当的假对照相比，我们的方案中使用 rTMS 对 PD 患者的睡眠没有治疗价值。未来评估 rTMS 对 PD 睡眠可能的治疗作用的研究应控制安慰剂的影响。
