子痫前期女性的氧化应激与免疫改变
Oxidative stress and immunological alteration in women with preeclampsia.
作者信息
Silva Danilla Michelle Costa e, Marreiro Dilina do Nascimento, Moita Neto José Machado, Brito José Araújo, Neta Eunice Alves da Silva, Matias Juliana Paz, Sampaio Fabiane Araújo, Nogueira Nadir do Nascimento
机构信息
Nutrition Department, Federal University of Piauí, Teresina, Brazil.
出版信息
Hypertens Pregnancy. 2013 Aug;32(3):304-11. doi: 10.3109/10641955.2013.806540.
OBJECTIVES
To determine plasma concentrations of malondialdehyde (MDA) and of inflammatory markers in women with preeclampsia.
METHODS
A case-control study was conducted on 50 preeclamptic and 50 healthy pregnant women. The concentrations of MDA were determined by the method of thiobarbituric acid reactive substances. Markers of inflammation were determined by the multiplex method.
RESULTS
The concentrations of MDA did not differ between groups (p > 0.05) and the preeclampsia group had significantly higher IL-6, IL-10, TNF-α and IL-6/IL-10 ratio, compared to those with normal pregnancy.
CONCLUSIONS
The MDA is a nonspecific marker for oxidative stress in preeclampsia, and the gestantes with preeclampsia have immune dysfunction.
目的
测定子痫前期妇女血浆中丙二醛（MDA）浓度及炎症标志物水平。
方法
对50例子痫前期孕妇和50例健康孕妇进行病例对照研究。采用硫代巴比妥酸反应物质法测定MDA浓度。采用多重方法测定炎症标志物。
结果
两组间MDA浓度无差异（p>0.05），与正常妊娠孕妇相比，子痫前期组白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）及IL-6/IL-10比值显著升高。
结论
MDA是子痫前期氧化应激的非特异性标志物，子痫前期孕妇存在免疫功能紊乱。
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