Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy.
Biomark Med. 2013 Aug;7(4):633-9. doi: 10.2217/bmm.13.49.
Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease.
MATERIALS & METHODS: Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age: 47 ± 12 years; BMI: 36 ± 5 kg/m(2)) and in 306 over- and normal-weight subjects (112 males, 194 females; age: 47 ± 12 years; BMI: 24 ± 3 kg/m(2)).
d-ROMs levels were higher in obese than in over- and normal-weight subjects (395 ± 104 vs 362 ± 102 and 351 ± 84 arbitrary units (AU); p < 0.001), in women than males (390 ± 104 vs 327 ± 68 AU; p < 0.001), in subjects with than those without hypertension (390 ± 103 vs 360 ± 95 AU; p < 0.01) and in smokers than former and nonsmokers (380 ± 97 vs 358 ± 97 AU; p < 0.05). A positive correlation was found between d-ROMs and BMI (r = 0.25; p < 0.001) and age (r = 0.13; p < 0.01). Levels of d-ROM (>75th percentile: 420 AU) remained as an independent obesity predictor (odds ratio: 2.5; p < 0.001) in women. Continuous variables are reported as mean ± standard deviation.
d-ROMs are a powerful obesity predictor, and could represent a reliable tool in obesity and cardiovascular risk evaluation, especially in women.
氧化应激被认为是将肥胖与心血管疾病联系起来的一个附加因素。
在 136 名肥胖者（42 名男性，94 名女性；平均年龄：47 ± 12 岁；BMI：36 ± 5 kg/m²）和 306 名超重和正常体重者（112 名男性，194 名女性；年龄：47 ± 12 岁；BMI：24 ± 3 kg/m²）中测量了活性氧代谢物（d-ROMs）的衍生物。
与超重和正常体重者相比，肥胖者的 d-ROMs 水平更高（395 ± 104 比 362 ± 102 和 351 ± 84 任意单位（AU）；p < 0.001），女性高于男性（390 ± 104 比 327 ± 68 AU；p < 0.001），高血压者高于无高血压者（390 ± 103 比 360 ± 95 AU；p < 0.01），吸烟者高于曾经吸烟者和非吸烟者（380 ± 97 比 358 ± 97 AU；p < 0.05）。d-ROMs 与 BMI（r = 0.25；p < 0.001）和年龄（r = 0.13；p < 0.01）呈正相关。d-ROMs 水平（>75 百分位数：420 AU）仍然是女性肥胖的独立预测因素（优势比：2.5；p < 0.001）。连续变量以平均值 ± 标准差表示。
d-ROMs 是肥胖的有力预测指标，特别是在女性中，它可能是肥胖和心血管风险评估的可靠工具。
