Khadir Abdelkrim, Tiss Ali, Kavalakatt Sina, Behbehani Kazem, Dehbi Mohammed, Elkum Naser
Department of Biomedical Research, Dasman Diabetes Institute, 15462 Kuwait City, Kuwait.
Diabetes Research Centre, Qatar Biomedical Research Institute, Doha, Qatar.
Mediators Inflamm. 2015;2015:512603. doi: 10.1155/2015/512603. Epub 2015 Mar 31.
The impact of gender difference on the association between metabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses and assessed their correlation with classical cardiometabolites in Arab population.
A total of 378 adult Arab participants (193 females) were enrolled in this cross-sectional study. Plasma levels of CRP, IL-6, IL-8, TNF-α, ROS, TBARs, and PON1 were measured and correlated with anthropometric and cardiometabolite parameters of the study population.
Compared to females, males had significantly higher FBG, HbA1c, TG, and blood pressure but lower BMI, TC, and HDL (P < 0.05). After adjustment for BMI and WC, females had higher levels of ROS, TBARS, and CRP (P < 0.001) whereas males had increased levels of IL-8, IL-6, and TNF-α (P < 0.05). Moreover, after adjustment for age, BMI, and gender, the levels of TNF-α, IL-6, and ROS were associated with central obesity but not general obesity.
Inflammation and oxidative stress contribution to CVD risk in Arab population linked to gender and this risk is better reflected by central obesity. Arab females might be at risk of CVD complications due to increased oxidative stress.
性别差异对代谢应激与心血管疾病（CVD）之间关联的影响仍不明确。我们首次研究了阿拉伯人群中性别对氧化应激和炎症应激反应的影响，并评估了它们与经典心脏代谢物的相关性。
共有378名成年阿拉伯参与者（193名女性）纳入了这项横断面研究。测量了血浆中CRP、IL-6、IL-8、TNF-α、ROS、TBARs和PON1的水平，并将其与研究人群的人体测量和心脏代谢参数进行关联分析。
与女性相比，男性的空腹血糖（FBG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）和血压显著更高，但体重指数（BMI）、总胆固醇（TC）和高密度脂蛋白（HDL）更低（P < 0.05）。在调整BMI和腰围（WC）后，女性的ROS、TBARS和CRP水平更高（P < 0.001），而男性的IL-8、IL-6和TNF-α水平升高（P < 0.05）。此外，在调整年龄、BMI和性别后，TNF-α、IL-6和ROS水平与中心性肥胖相关，但与全身性肥胖无关。
在阿拉伯人群中，炎症和氧化应激对CVD风险的影响与性别有关，且这种风险通过中心性肥胖能得到更好的体现。阿拉伯女性可能因氧化应激增加而面临CVD并发症的风险。
