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三种不同止汗剂剂型在应激性出汗时的止汗效率。

Efficient sweat reduction of three different antiperspirant application forms during stress-induced sweating.

机构信息

Research & Development, Beiersdorf AG, Unnastrasse 48, 20245, Hamburg, Germany.

出版信息

Int J Cosmet Sci. 2013 Dec;35(6):622-31. doi: 10.1111/ics.12086. Epub 2013 Sep 2.

DOI:10.1111/ics.12086
PMID:23906286
Abstract

OBJECTIVES

Stress sweating can occur in everyday situations independently of thermally-induced perspiration. It is triggered by emotionally challenging situations and leads to underarm wetness and a characteristic unpleasant malodor. In this study, we aimed to determine the long-term efficacy of three unperfumed antiperspirant (AP) formulas for different application forms (roll-on, stick, aerosol) against stress-induced sweating and malodor formation.

METHODS

We utilized the widely accepted Trier Social Stress Test (TSST) to induce psychosocial stress in female and male volunteers (18 - 40 years) and determined physiological stress parameters. To additionally assess the efficacy of the test AP roll-on against thermally-induced sweating, a hot room study was performed.

RESULTS

Increasing heart rates and an augmentation of saliva cortisol levels during the TSST indicated a substantial stress reaction which was paralleled by a pronounced sweat production in the untreated axillae of both males and females. Forty-eight hours after application, all three test APs significantly decreased the amount of sweat in the treated axillae independent of gender. With respect to AP effects on malodor production, trained sniffers assessed sweat samples collected during the TSST from the untreated axillae as significantly more malodorous than comparable samples from the AP-treated axillae. Also, independent of gender the test AP roll-on significantly decreased the thermally-induced sweat in the AP-treated axilla.

CONCLUSION

We show for the first time a highly effective reduction of emotionally-induced axillary sweating and malodor production for three different application forms 48 h after the last product use. The specially developed roll-on, stick, and aerosol AP provide long-term protection against stress-induced sweat which is of high relevance in everyday life.

摘要

目的

应激性出汗可在日常情况下发生,且不依赖于热诱导性出汗。它由情绪挑战性的情况触发,导致腋窝潮湿和特征性的不愉快气味。在这项研究中,我们旨在确定三种无香味止汗剂(AP)配方(滚涂式、棒状、喷雾式)在不同应用形式下(滚涂式、棒状、喷雾式)对应激性出汗和气味形成的长期疗效。

方法

我们利用广泛接受的特里尔社会应激测试(TSST)在女性和男性志愿者(18-40 岁)中诱发心理社会应激,并确定生理应激参数。为了进一步评估测试 AP 滚涂式对热诱导性出汗的疗效,进行了热室研究。

结果

TSST 期间心率的增加和唾液皮质醇水平的升高表明存在明显的应激反应,这与男女未处理腋窝的明显出汗增加相平行。应用 48 小时后,所有三种测试 AP 均显著减少了男女未处理腋窝的出汗量。关于 AP 对气味产生的影响,受过训练的嗅探器评估了未处理腋窝在 TSST 期间收集的汗液样本,认为其气味明显比 AP 处理腋窝的汗液样本更难闻。此外,无论性别如何,测试 AP 滚涂式均显著减少了 AP 处理腋窝的热诱导性出汗。

结论

我们首次显示,在最后一次使用产品 48 小时后,三种不同应用形式的情绪诱导性腋窝出汗和气味产生可得到高度有效的减少。专门开发的滚涂式、棒状和喷雾式 AP 提供了对应激性出汗的长期保护,这在日常生活中具有重要意义。

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