氨酰化转移 RNA 的方向与抗生素合成及肽聚糖介导的抗生素耐药性有关。
Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan-mediated antibiotic resistance.
机构信息
Department of Microbiology and Center for RNA Biology, Ohio State University, Columbus, OH 43210-1292, USA.
出版信息
FEBS Lett. 2013 Sep 17;587(18):2895-904. doi: 10.1016/j.febslet.2013.07.036. Epub 2013 Jul 29.
Abstract
Prokaryotic aminoacylated-transfer RNAs often need to be efficiently segregated between translation and other cellular biosynthetic pathways. Many clinically relevant bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa direct some aminoacylated-tRNA species into peptidoglycan biosynthesis and/or membrane phospholipid modification. Subsequent indirect peptidoglycan cross-linkage or change in membrane permeability is often a prerequisite for high-level antibiotic resistance. In Streptomycetes, aminoacylated-tRNA species are used for antibiotic synthesis as well as antibiotic resistance. The direction of coding aminoacylated-tRNA molecules away from translation and into antibiotic resistance and synthesis pathways are discussed in this review.
摘要
原核生物氨酰化转移 RNA 通常需要在翻译和其他细胞生物合成途径之间进行有效的分离。许多与临床相关的细菌，包括肺炎链球菌、金黄色葡萄球菌、粪肠球菌和铜绿假单胞菌，将一些氨酰化 tRNA 定向进入肽聚糖生物合成和/或膜磷酯质修饰。随后间接的肽聚糖交联或膜通透性的改变通常是高水平抗生素耐药性的前提。在链霉菌中，氨酰化 tRNA 用于抗生素合成和抗生素耐药性。本文综述了氨酰化 tRNA 分子从翻译到抗生素耐药性和合成途径的定向。
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