Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Trends Neurosci. 2013 Oct;36(10):598-609. doi: 10.1016/j.tins.2013.06.008. Epub 2013 Jul 30.
Voltage-gated calcium ion (CaV) channels convert neuronal activity into rapid intracellular calcium signals to trigger a myriad of cellular responses. Their involvement in major neurological and psychiatric diseases, and importance as therapeutic targets, has propelled interest in subcellular-specific mechanisms that align CaV channel activity to specific tasks. Here, we highlight recent studies that delineate mechanisms controlling the expression of CaV channels at the level of RNA and protein. We discuss the roles of RNA editing and alternative pre-mRNA splicing in generating CaV channel isoforms with activities specific to the demands of individual cells; the roles of ubiquitination and accessory proteins in regulating CaV channel expression; and the specific binding partners that contribute to both pre- and postsynaptic CaV channel function.
电压门控钙离子（CaV）通道将神经元活动转化为快速的细胞内钙离子信号，从而引发多种细胞反应。它们在主要的神经和精神疾病中的作用以及作为治疗靶点的重要性，促使人们对将 CaV 通道活性与特定任务相匹配的亚细胞特异性机制产生了兴趣。在这里，我们重点介绍了最近的研究，这些研究描绘了控制 RNA 和蛋白质水平 CaV 通道表达的机制。我们讨论了 RNA 编辑和选择性前体 mRNA 剪接在产生具有特定于单个细胞需求的 CaV 通道同工型方面的作用；泛素化和辅助蛋白在调节 CaV 通道表达中的作用；以及有助于突触前和突触后 CaV 通道功能的特定结合伙伴。
