驱动蛋白-8 的多重功能。
The multiple talents of kinesin-8.
机构信息
London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
出版信息
Nat Cell Biol. 2013 Aug;15(8):889-91. doi: 10.1038/ncb2820.
DOI:10.1038/ncb2820
PMID:23907192
Abstract
Multiple activities cooperate to determine the architecture of the mitotic spindle. Kip3 is a kinesin-8 motor protein in budding yeast that acts as a microtubule depolymerase. Now Kip3 is shown to also crosslink and slide antiparallel microtubules, providing additional insights into how kinesin-8 motors control spindle integrity.
摘要
多种活动协同作用决定有丝分裂纺锤体的结构。Kip3 是芽殖酵母中的一种 kinesin-8 运动蛋白，作为微管解聚酶发挥作用。现在表明 Kip3 还能交联和滑动反平行微管，这为了解 kinesin-8 马达如何控制纺锤体完整性提供了更多的见解。
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